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DYNC1H1 elisa kit :: Bovine Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7251460 DYNC1H1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1), ELISA Kit

 Also Known As   

Bovine Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA Kit

 Product Gene Name   

DYNC1H1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    614563
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact technical support.
 Other Notes    Small volumes of DYNC1H1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DYNC1H1 purchase    MBS7251460 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DYNC1H1. The ELISA analytical biochemical technique of the MBS7251460 kit is based on DYNC1H1 antibody-DYNC1H1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DYNC1H1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DYNC1H1. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for DYNC1H1 elisa kit    Neurobiology
NCBI/Uniprot data below describe general gene information for DYNC1H1. It may not necessarily be applicable to this product.
 NCBI GI #    33350932
 NCBI GeneID    1778
 NCBI Accession #    NP_001367.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001376.4 [Other Products]
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 UniProt Secondary Accession #    Q6DKQ7; Q8WU28; Q92814; Q9Y4G5; B0I1R0 [Other Products]
 UniProt Related Accession #    Q14204 [Other Products]
 Molecular Weight    532,408 Da
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 NCBI Official Full Name    cytoplasmic dynein 1 heavy chain 1
 NCBI Official Synonym Full Names    dynein, cytoplasmic 1, heavy chain 1
 NCBI Official Symbol    DYNC1H1 [Similar Products]
 NCBI Official Synonym Symbols   
p22; DHC1; DNCL; DYHC; HL-3; DHC1a; DNCH1; DNECL; Dnchc1; SMALED1
[Similar Products]
 NCBI Protein Information    cytoplasmic dynein 1 heavy chain 1; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy polypeptide 1
 UniProt Protein Name    Cytoplasmic dynein 1 heavy chain 1
 UniProt Synonym Protein Names   
Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic
 Protein Family    Cytoplasmic dynein
 UniProt Gene Name    DYNC1H1 [Similar Products]
 UniProt Synonym Gene Names    DHC1; DNCH1; DNCL; DNECL; DYHC; KIAA0325 [Similar Products]
 UniProt Entry Name    DYHC1_HUMAN
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 NCBI Summary for DYNC1H1    Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
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 UniProt Comments for DYNC1H1    DNCH1: Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Defects in DYNC1H1 are the cause of Charcot-Marie-Tooth disease type 2O (CMT2O). CMT2O is anaxonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Defects in DYNC1H1 are the cause of mental retardation autosomal dominant type 13 (MRD13). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD13 is associated with variable neuronal migration defects and mild dysmorphic features. Some patients may also show signs of peripheral neuropathy, such as abnormal gait and hyporeflexia. Defects in DYNC1H1 are the cause of spinal muscular atrophy, lower extremity, autosomal dominant (SMALED). A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMALED is characterized by muscle weakness predominantly affecting the proximal lower extremities. Belongs to the dynein heavy chain family.

Protein type: Motor; Motility/polarity/chemotaxis; Microtubule-binding

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: centrosome; microtubule; cytoplasmic dynein complex; membrane; cytosol; filopodium

Molecular Function: protein binding; ATPase activity; dynein light intermediate chain binding; microtubule motor activity; ATP binding

Biological Process: stress granule assembly; mitotic spindle organization and biogenesis; metabolic process; transport; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytoplasmic mRNA processing body assembly; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based movement

Disease: Charcot-marie-tooth Disease, Axonal, Type 2o; Spinal Muscular Atrophy, Lower Extremity-predominant, 1, Autosomal Dominant; Mental Retardation, Autosomal Dominant 13
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 Research Articles on DYNC1H1    1. This study demonistrated that DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DYNC1H1 elisa kitPathways associated with DYNC1H1 elisa kit
 Reference Product  PubMed Publications
 DCTN1 elisa kit  >2 publications with DYNC1H1 and DCTN1
 DYNLL1 elisa kit  >1 publications with DYNC1H1 and DYNLL1
 PAFAH1B1 elisa kit  >1 publications with DYNC1H1 and PAFAH1B1
 NDEL1 elisa kit  >1 publications with DYNC1H1 and NDEL1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
Diseases associated with DYNC1H1 elisa kitOrgans/Tissues associated with DYNC1H1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >22 publications with DYNC1H1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >8 publications with DYNC1H1 and Congenital Abnormalities
 Malformations of Cortical Development Antibodies  >4 publications with DYNC1H1 and Malformations of Cortical Development
 Intellectual Disability Antibodies  >3 publications with DYNC1H1 and Intellectual Disability
 Adenocarcinoma Antibodies  >1 publications with DYNC1H1 and Adenocarcinoma
 Infertility, Male Antibodies  >1 publications with DYNC1H1 and Infertility, Male
 Microcephaly Antibodies  >1 publications with DYNC1H1 and Microcephaly
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with DYNC1H1 and Brain
 Nerve Antibodies  >7 publications with DYNC1H1 and Nerve
 Muscle Antibodies  >7 publications with DYNC1H1 and Muscle
 Embryonic Tissue Antibodies  >2 publications with DYNC1H1 and Embryonic Tissue
 Ganglia Antibodies  >2 publications with DYNC1H1 and Ganglia
 Trachea Antibodies  >1 publications with DYNC1H1 and Trachea
 Heart Antibodies  >1 publications with DYNC1H1 and Heart
 Pancreas Antibodies  >1 publications with DYNC1H1 and Pancreas
 Blood Antibodies  >1 publications with DYNC1H1 and Blood
 Eye Antibodies  >1 publications with DYNC1H1 and Eye
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