NP_001267468.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,256 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase RNF19A
NCBI Official Synonym Full Names
ring finger protein 19A, RBR E3 ubiquitin protein ligase
NCBI Official Synonym Symbols
NCBI Protein Information
E3 ubiquitin-protein ligase RNF19A; ring finger protein 19; double ring-finger protein; ring-IBR-ring domain containing protein Dorfin; ring finger protein 19A, E3 ubiquitin protein ligase; protein p38 interacting with transcription factor Sp1
UniProt Protein Name
E3 ubiquitin-protein ligase RNF19A
UniProt Synonym Protein Names
Double ring-finger protein; Dorfin; RING finger protein 19A; p38
UniProt Synonym Gene Names
UniProt Entry Name
RN19A_HUMAN
NCBI Summary for RNF19A
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for RNF19A
RNF19: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. Belongs to the RBR family. RNF19 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Ligase; EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.-; Transcription, coactivator/corepressor; Membrane protein, multi-pass; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: centrosome; cytoplasm; integral to membrane
Molecular Function: zinc ion binding; transcription factor binding; ligase activity
Biological Process: protein ubiquitination; microtubule cytoskeleton organization and biogenesis
Research Articles on RNF19A
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Products associated with RNF19A elisa kit
Pathways associated with RNF19A elisa kit
Diseases associated with RNF19A elisa kit
Organs/Tissues associated with RNF19A elisa kit
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