CAG33314.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
48,115 Da
NCBI Official Full Name
FDFT1
NCBI Official Synonym Full Names
farnesyl-diphosphate farnesyltransferase 1
NCBI Protein Information
squalene synthase; squalene synthetase; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase
UniProt Protein Name
FDFT1 protein
UniProt Synonym Protein Names
FDFT1 protein; Farnesyl-diphosphate farnesyltransferase 1; Farnesyl-diphosphate farnesyltransferase 1, isoform CRA_a
UniProt Synonym Gene Names
UniProt Entry Name
Q6IAX1_HUMAN
NCBI Summary for FDFT1
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
UniProt Comments for FDFT1
FDFT1: a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Protein type: Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; Transferase; Membrane protein, multi-pass; EC 2.5.1.21; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p23.1-p22
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: farnesyl-diphosphate farnesyltransferase activity; oxidoreductase activity
Biological Process: isoprenoid biosynthetic process; farnesyl diphosphate metabolic process; cellular lipid metabolic process; cholesterol biosynthetic process; steroid biosynthetic process
Research Articles on FDFT1
Precautions
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Pathways associated with FDFT1 elisa kit
Diseases associated with FDFT1 elisa kit
Organs/Tissues associated with FDFT1 elisa kit
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