EAW74853.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,280 Da
NCBI Official Full Name
folate receptor 2 (fetal)
NCBI Official Synonym Full Names
folate receptor 2 (fetal)
NCBI Official Synonym Symbols
FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1 [Similar Products]
NCBI Protein Information
folate receptor beta
UniProt Protein Name
Folate receptor beta
UniProt Synonym Protein Names
Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein; FBP
UniProt Synonym Gene Names
UniProt Entry Name
FOLR2_HUMAN
NCBI Summary for FOLR2
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for FOLR2
FOLR2: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Belongs to the folate receptor family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 11q13.3-q13.5
Cellular Component: anchored to external side of plasma membrane; cell surface; extracellular region; membrane
Molecular Function: drug binding; folic acid binding; folic acid transporter activity; methotrexate binding
Biological Process: folic acid transport; inflammatory response; monocyte chemotaxis; positive regulation of cell proliferation; receptor-mediated endocytosis; regulation of thymidylate synthase biosynthetic process
Research Articles on FOLR2
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Products associated with FOLR2 elisa kit
Pathways associated with FOLR2 elisa kit
Diseases associated with FOLR2 elisa kit
Organs/Tissues associated with FOLR2 elisa kit
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