NP_036315.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,630 Da
NCBI Official Full Name
forkhead box protein D3
NCBI Official Synonym Full Names
forkhead box D3
NCBI Protein Information
forkhead box protein D3; HNF3/FH transcription factor genesis
UniProt Protein Name
Forkhead box protein D3
UniProt Synonym Protein Names
HNF3/FH transcription factor genesis
UniProt Synonym Gene Names
UniProt Entry Name
FOXD3_HUMAN
NCBI Summary for FOXD3
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
UniProt Comments for FOXD3
FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: nucleoplasm; nuclear chromatin
Molecular Function: protein binding; double-stranded DNA binding; transcription factor activity
Biological Process: embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation
Disease: Autoimmune Disease, Susceptibility To, 1
Research Articles on FOXD3
Precautions
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Disclaimer
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Products associated with FOXD3 elisa kit
Pathways associated with FOXD3 elisa kit
Diseases associated with FOXD3 elisa kit
Disease Name |
Pubmed Publications |
Drug Toxicity Antibodies |
>2 publications with FOXD3 and Drug Toxicity |
Abnormalities, Multiple Antibodies |
>2 publications with FOXD3 and Abnormalities, Multiple |
Sarcoma Antibodies |
>2 publications with FOXD3 and Sarcoma |
Ovarian Neoplasms Antibodies |
>1 publications with FOXD3 and Ovarian Neoplasms |
Heart Defects, Congenital Antibodies |
>1 publications with FOXD3 and Heart Defects, Congenital |
Necrosis Antibodies |
>1 publications with FOXD3 and Necrosis |
Respiratory Tract Diseases Antibodies |
>1 publications with FOXD3 and Respiratory Tract Diseases |
Abnormalities, Drug-Induced Antibodies |
>1 publications with FOXD3 and Abnormalities, Drug-Induced |
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1 Antibodies |
>1 publications with FOXD3 and AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1 |
Organs/Tissues associated with FOXD3 elisa kit
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