NP_002515.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,229 Da
NCBI Official Full Name
GTPase NRas
NCBI Official Synonym Full Names
neuroblastoma RAS viral (v-ras) oncogene homolog
NCBI Official Synonym Symbols
NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1 [Similar Products]
NCBI Protein Information
GTPase NRas; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
UniProt Protein Name
GTPase NRas
UniProt Synonym Protein Names
Transforming protein N-Ras
UniProt Synonym Gene Names
UniProt Entry Name
RASN_HUMAN
NCBI Summary for NRAS
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
UniProt Comments for NRAS
NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.
Protein type: Oncoprotein; G protein, monomeric, Ras; G protein; Motility/polarity/chemotaxis; G protein, monomeric
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: Golgi membrane; membrane; plasma membrane
Molecular Function: GTP binding; protein complex binding
Biological Process: epidermal growth factor receptor signaling pathway; regulation of long-term neuronal synaptic plasticity; axon guidance; negative regulation of skeletal muscle development; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; MAPKKK cascade; regulation of synaptic transmission, GABAergic; positive regulation of Rac protein signal transduction; negative regulation of cell differentiation; small GTPase mediated signal transduction; Ras protein signal transduction; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; visual learning; striated muscle cell differentiation; negative regulation of neuron apoptosis; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis; blood coagulation; leukocyte migration
Disease: Thyroid Carcinoma, Follicular; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Noonan Syndrome 6; Colorectal Cancer; Melanocytic Nevus Syndrome, Congenital; Melanosis, Neurocutaneous; Nevus, Epidermal
Research Articles on NRAS
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Products associated with NRAS elisa kit
Pathways associated with NRAS elisa kit
Diseases associated with NRAS elisa kit
Disease Name |
Pubmed Publications |
Melanoma Antibodies |
>424 publications with NRAS and Melanoma |
Colorectal Neoplasms Antibodies |
>79 publications with NRAS and Colorectal Neoplasms |
Cell Transformation, Neoplastic Antibodies |
>64 publications with NRAS and Cell Transformation, Neoplastic |
Lung Neoplasms Antibodies |
>52 publications with NRAS and Lung Neoplasms |
Neoplasms, Experimental Antibodies |
>52 publications with NRAS and Neoplasms, Experimental |
Lymphoma Antibodies |
>49 publications with NRAS and Lymphoma |
Neuroblastoma Antibodies |
>43 publications with NRAS and Neuroblastoma |
Nervous System Diseases Antibodies |
>38 publications with NRAS and Nervous System Diseases |
Leukemia, Myelomonocytic, Juvenile Antibodies |
>36 publications with NRAS and Leukemia, Myelomonocytic, Juvenile |
Thyroid cancer, follicular Antibodies |
>32 publications with NRAS and Thyroid cancer, follicular |
Organs/Tissues associated with NRAS elisa kit
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