NP_000882.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,288 Da
NCBI Official Full Name
inward rectifier potassium channel 2
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 2
NCBI Official Synonym Symbols
IRK1; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1 [Similar Products]
NCBI Protein Information
inward rectifier potassium channel 2
UniProt Protein Name
Inward rectifier potassium channel 2
UniProt Synonym Protein Names
Cardiac inward rectifier potassium channel; Inward rectifier K(+) channel Kir2.1; IRK-1; hIRK1; Potassium channel, inwardly rectifying subfamily J member 2
UniProt Synonym Gene Names
UniProt Entry Name
KCNJ2_HUMAN
NCBI Summary for KCNJ2
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ2
KCNJ2: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7); also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features. Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves. Defects in KCNJ2 are the cause of familial atrial fibrillation type 9 (ATFB9). ATFB9 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q24.3
Cellular Component: cell soma; dendritic spine; Golgi apparatus; integral to plasma membrane; intrinsic to membrane; plasma membrane; rough endoplasmic reticulum; smooth endoplasmic reticulum; T-tubule; voltage-gated potassium channel complex
Molecular Function: identical protein binding; inward rectifier potassium channel activity; phosphatidylinositol-4,5-bisphosphate binding
Biological Process: cellular potassium ion homeostasis; magnesium ion transport; potassium ion import; potassium ion transport; protein homotetramerization; regulation of resting membrane potential; regulation of skeletal muscle contraction via membrane action potential; synaptic transmission
Disease: Andersen Cardiodysrhythmic Periodic Paralysis; Atrial Fibrillation, Familial, 9; Short Qt Syndrome 3
Research Articles on KCNJ2
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Products associated with KCNJ2 elisa kit
Pathways associated with KCNJ2 elisa kit
Diseases associated with KCNJ2 elisa kit
Organs/Tissues associated with KCNJ2 elisa kit
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