NP_001106878.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,533 Da
NCBI Official Full Name
LIM domain-binding protein 1 isoform 1
NCBI Official Synonym Full Names
LIM domain binding 1
NCBI Official Synonym Symbols
NCBI Protein Information
LIM domain-binding protein 1; LDB-1; hLdb1; CLIM-2; nuclear LIM interactor; LIM domain-binding factor-1; LIM domain-binding factor CLIM2; carboxy terminal LIM domain protein 2; carboxyl-terminal LIM domain-binding protein 2
UniProt Protein Name
LIM domain-binding protein 1
UniProt Synonym Protein Names
Carboxyl-terminal LIM domain-binding protein 2; CLIM-2; LIM domain-binding factor CLIM2; hLdb1; Nuclear LIM interactor
UniProt Synonym Gene Names
UniProt Entry Name
LDB1_HUMAN
UniProt Comments for LDB1
LDB1: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Belongs to the LDB family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10q24-q25
Cellular Component: transcription factor complex; protein complex; nuclear chromatin; nucleus
Molecular Function: LIM domain binding; enzyme binding; protein homodimerization activity; protein self-association; chromatin binding; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of erythrocyte differentiation; positive regulation of cell adhesion; Wnt receptor signaling pathway; transcription, DNA-dependent; somatic stem cell maintenance; multicellular organismal development; gastrulation with mouth forming second; positive regulation of hemoglobin biosynthetic process; cellular component assembly; neuron differentiation; hair follicle development; regulation of transcription, DNA-dependent; cerebellar Purkinje cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of RNA elongation; anterior/posterior axis specification
Research Articles on LDB1
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Products associated with LDB1 elisa kit
Pathways associated with LDB1 elisa kit
Diseases associated with LDB1 elisa kit
Organs/Tissues associated with LDB1 elisa kit
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