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LIFR elisa kit :: Bovine Leukemia Inhibitory Factor Receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS044478 LIFR elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leukemia Inhibitory Factor Receptor (LIFR), ELISA Kit

 Also Known As   

Bovine Leukemia Inhibitory Factor Receptor ELISA Kit

 Product Gene Name   

LIFR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 5; NC_000005.9 (38475065..38595507, complement). Location: 5p13-p12
 OMIM    151443
 3D Structure    ModBase 3D Structure for P42702
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 Species Reactivity    Bovine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LIFR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LIFR purchase    MBS044478 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Leukemia Inhibitory Factor Receptor (LIFR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LIFR. The ELISA analytical biochemical technique of the MBS044478 kit is based on LIFR antibody-LIFR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LIFR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LIFR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for LIFR. It may not necessarily be applicable to this product.
 NCBI GI #    189083786
 NCBI GeneID    3977
 NCBI Accession #    NP_001121143.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127671.1 [Other Products]
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 UniProt Primary Accession #    P42702 [Other Products]
 UniProt Secondary Accession #    Q6LCD9 [Other Products]
 UniProt Related Accession #    P42702 [Other Products]
 Molecular Weight    123,743 Da
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 NCBI Official Full Name    leukemia inhibitory factor receptor
 NCBI Official Synonym Full Names    leukemia inhibitory factor receptor alpha
 NCBI Official Symbol    LIFR [Similar Products]
 NCBI Official Synonym Symbols   
SWS; SJS2; STWS; CD118; LIF-R
[Similar Products]
 NCBI Protein Information    leukemia inhibitory factor receptor; LIF receptor; CD118 antigen
 UniProt Protein Name    Leukemia inhibitory factor receptor
 Protein Family    Leukemia inhibitory factor receptor
 UniProt Gene Name    LIFR [Similar Products]
 UniProt Synonym Gene Names    LIF receptor; LIF-R [Similar Products]
 UniProt Entry Name    LIFR_HUMAN
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 NCBI Summary for LIFR    This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LIFR    LIFR: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS); also knowns as Schwartz-Jampel syndrome type 2 (SJS2). SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue. A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function: leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding

Biological Process: cell surface receptor linked signal transduction; leukemia inhibitory factor signaling pathway; response to cytokine stimulus; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation

Disease: Stuve-wiedemann Syndrome
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 Research Articles on LIFR    1. LIFR rs3729740 and possibly ANXA11 rs1049550 may be useful as biomarkers for predicting whether metastatic colorectal cancer patients are sensitive to relevant target regimens, although further validation in large cohorts is needed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LIFR elisa kitPathways associated with LIFR elisa kit
 Reference Product  PubMed Publications
 LIF elisa kit  >449 publications with LIFR and LIF
 OSM elisa kit  >384 publications with LIFR and OSM
 CNTF elisa kit  >127 publications with LIFR and CNTF
 IL6ST elisa kit  >118 publications with LIFR and IL6ST
 STAT3 elisa kit  >106 publications with LIFR and STAT3
 CNTFR elisa kit  >43 publications with LIFR and CNTFR
 JAK2 elisa kit  >15 publications with LIFR and JAK2
 PTPN6 elisa kit  >5 publications with LIFR and PTPN6
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
Diseases associated with LIFR elisa kitOrgans/Tissues associated with LIFR elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >87 publications with LIFR and Neoplasms
 Nervous System Diseases Antibodies  >39 publications with LIFR and Nervous System Diseases
 Inflammation Antibodies  >35 publications with LIFR and Inflammation
 Cardiovascular Diseases Antibodies  >23 publications with LIFR and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >20 publications with LIFR and Disease Models, Animal
 Necrosis Antibodies  >19 publications with LIFR and Necrosis
 Liver Diseases Antibodies  >16 publications with LIFR and Liver Diseases
 Hypertrophy Antibodies  >16 publications with LIFR and Hypertrophy
 Adenocarcinoma Antibodies  >13 publications with LIFR and Adenocarcinoma
 Liver Neoplasms Antibodies  >9 publications with LIFR and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >70 publications with LIFR and Nerve
 Brain Antibodies  >67 publications with LIFR and Brain
 Uterus Antibodies  >43 publications with LIFR and Uterus
 Embryonic Tissue Antibodies  >41 publications with LIFR and Embryonic Tissue
 Muscle Antibodies  >38 publications with LIFR and Muscle
 Liver Antibodies  >31 publications with LIFR and Liver
 Placenta Antibodies  >26 publications with LIFR and Placenta
 Heart Antibodies  >22 publications with LIFR and Heart
 Vascular Antibodies  >12 publications with LIFR and Vascular
 Ganglia Antibodies  >11 publications with LIFR and Ganglia
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