NP_075209.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
95,089 Da
NCBI Official Full Name
metabotropic glutamate receptor 6
NCBI Official Synonym Full Names
glutamate receptor, metabotropic 6
NCBI Official Synonym Symbols
NCBI Protein Information
metabotropic glutamate receptor 6
UniProt Protein Name
Metabotropic glutamate receptor 6
UniProt Synonym Gene Names
UniProt Entry Name
GRM6_RAT
NCBI Summary for GRM6
has adenylate cyclase inhibiting metabotropic glutamate receptor activity; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina [RGD, Feb 2006]
UniProt Comments for GRM6
mGluR6: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B). This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background. Belongs to the G-protein coupled receptor 3 family.
Protein type: Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral
Cellular Component: presynaptic membrane; Golgi membrane; endoplasmic reticulum membrane; integral to plasma membrane; dendrite; integral to membrane
Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; protein homodimerization activity; group III metabotropic glutamate receptor activity; glutamate receptor activity
Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; retina development in camera-type eye; sensory perception of light stimulus; metabotropic glutamate receptor signaling pathway; detection of light stimulus involved in visual perception; locomotory behavior; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; signal transduction
Research Articles on GRM6
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Products associated with GRM6 elisa kit
Pathways associated with GRM6 elisa kit
Diseases associated with GRM6 elisa kit
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