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MCM elisa kit :: Bovine Methylmalonyl-CoA Mutase, Mitochondrial (MCM) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9352552 MCM elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Methylmalonyl-CoA Mutase, Mitochondrial (MCM), ELISA Kit

 Also Known As   

Bovine Methylmalonyl-CoA Mutase, Mitochondrial (MCM) ELISA Kit

 Product Gene Name   

MCM elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    251000
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MCM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MCM purchase    MBS9352552 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Methylmalonyl-CoA Mutase, Mitochondrial (MCM) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MCM. The ELISA analytical biochemical technique of the MBS9352552 kit is based on MCM antibody-MCM antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MCM antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MCM. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for MCM. It may not necessarily be applicable to this product.
 NCBI GI #    156105689
 NCBI GeneID    4594
 NCBI Accession #    NP_000246.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000255.3 [Other Products]
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 UniProt Secondary Accession #    Q5SYZ3; Q96B11; Q9UD64; A8K953 [Other Products]
 UniProt Related Accession #    P22033 [Other Products]
 Molecular Weight    83,134 Da
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 NCBI Official Full Name    methylmalonyl-CoA mutase, mitochondrial
 NCBI Official Synonym Full Names    methylmalonyl-CoA mutase
 NCBI Official Symbol    MUT [Similar Products]
 NCBI Official Synonym Symbols   
MCM
[Similar Products]
 NCBI Protein Information    methylmalonyl-CoA mutase, mitochondrial
 UniProt Protein Name    Methylmalonyl-CoA mutase, mitochondrial
 UniProt Synonym Protein Names   
Methylmalonyl-CoA isomerase
 Protein Family    Minichromosome maintenance protein
 UniProt Gene Name    MUT [Similar Products]
 UniProt Synonym Gene Names    MCM [Similar Products]
 UniProt Entry Name    MUTA_HUMAN
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 NCBI Summary for MCM    This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MCM    MUT: Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species. Defects in MUT are the cause of methylmalonic aciduria type mut (MMAM). MMAM is an often fatal disorder of organic acid metabolism. Common clinical features include lethargy, vomiting, failure to thrive, hypotonia, neurological deficit and early death. Two forms of the disease are distinguished by the presence (mut-) or absence (mut0) of residual enzyme activity. Mut0 patients have more severe neurological manifestations of the disease than do MUT- patients. MMAM is unresponsive to vitamin B12 therapy. Belongs to the methylmalonyl-CoA mutase family.

Protein type: Carbohydrate Metabolism - propanoate; Isomerase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; EC 5.4.99.2

Chromosomal Location of Human Ortholog: 6p12.3

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: cobalamin binding; metal ion binding; methylmalonyl-CoA mutase activity

Biological Process: cellular lipid metabolic process; cobalamin metabolic process; fatty acid beta-oxidation; homocysteine metabolic process; post-embryonic development; short-chain fatty acid catabolic process; vitamin metabolic process; water-soluble vitamin metabolic process

Disease: Methylmalonic Aciduria Due To Methylmalonyl-coa Mutase Deficiency
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 Research Articles on MCM    1. data stratify MUT missense mutations into categories of biochemical defects, including (1) reduced protein level due to misfolding, (2) increased thermolability, (3) impaired enzyme activity, and (4) reduced cofactor response in substrate turnover
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MCM elisa kitPathways associated with MCM elisa kit
 Reference Product  PubMed Publications
 MMAA elisa kit  >13 publications with MCM and MMAA
 MMAB elisa kit  >9 publications with MCM and MMAB
 PCCB elisa kit  >5 publications with MCM and PCCB
 MCEE elisa kit  >5 publications with MCM and MCEE
 Products by Pathway  Pathway Diagram
 2-oxobutanoate Degradation Pathway antibodies  2-oxobutanoate Degradation Pathway Diagram
 2-oxobutanoate Degradation I Pathway antibodies  2-oxobutanoate Degradation I Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MUT Causes Methylmalonic Aciduria Mut Type Pathway antibodies  Defective MUT Causes Methylmalonic Aciduria Mut Type Pathway Diagram
 Defects In Cobalamin (B12) Metabolism Pathway antibodies  Defects In Cobalamin (B12) Metabolism Pathway Diagram
 Defects In Vitamin And Cofactor Metabolism Pathway antibodies  Defects In Vitamin And Cofactor Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with MCM elisa kitOrgans/Tissues associated with MCM elisa kit
 Disease Name  Pubmed Publications
 Metabolism, Inborn Errors Antibodies  >111 publications with MCM and Metabolism, Inborn Errors
 Methylmalonic acidemia Antibodies  >86 publications with MCM and Methylmalonic acidemia
 Cardiovascular Diseases Antibodies  >77 publications with MCM and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >60 publications with MCM and Disease Models, Animal
 Lung Diseases Antibodies  >45 publications with MCM and Lung Diseases
 Neoplasms, Experimental Antibodies  >36 publications with MCM and Neoplasms, Experimental
 Kidney Diseases Antibodies  >35 publications with MCM and Kidney Diseases
 Inflammation Antibodies  >34 publications with MCM and Inflammation
 Necrosis Antibodies  >34 publications with MCM and Necrosis
 Heart Diseases Antibodies  >33 publications with MCM and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >312 publications with MCM and Blood
 Brain Antibodies  >161 publications with MCM and Brain
 Liver Antibodies  >84 publications with MCM and Liver
 Lung Antibodies  >67 publications with MCM and Lung
 Bone Antibodies  >63 publications with MCM and Bone
 Kidney Antibodies  >63 publications with MCM and Kidney
 Heart Antibodies  >62 publications with MCM and Heart
 Muscle Antibodies  >62 publications with MCM and Muscle
 Vascular Antibodies  >47 publications with MCM and Vascular
 Skin Antibodies  >38 publications with MCM and Skin
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