NP_003042.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,234 Da
NCBI Official Full Name
monocarboxylate transporter 1
NCBI Official Synonym Full Names
solute carrier family 16 member 1
NCBI Protein Information
monocarboxylate transporter 1
UniProt Protein Name
Monocarboxylate transporter 1
UniProt Synonym Protein Names
Solute carrier family 16 member 1
UniProt Synonym Gene Names
NCBI Summary for MCT1
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for MCT1
MCT1: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT); also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7); also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: centrosome; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: lactate transmembrane transporter activity; mevalonate transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity
Biological Process: centrosome organization and biogenesis; leukocyte migration; mevalonate transport; monocarboxylic acid transport; pyruvate metabolic process
Disease: Erythrocyte Lactate Transporter Defect; Hyperinsulinemic Hypoglycemia, Familial, 7; Monocarboxylate Transporter 1 Deficiency
Research Articles on MCT1
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Products associated with MCT1 elisa kit
Pathways associated with MCT1 elisa kit
Diseases associated with MCT1 elisa kit
Organs/Tissues associated with MCT1 elisa kit
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