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PTH1R elisa kit :: Bovine Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor (PTH1R) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9357922 PTH1R elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor (PTH1R), ELISA Kit

 Also Known As   

Bovine Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor (PTH1R) ELISA Kit

 Product Gene Name   

PTH1R elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    125350
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PTH1R elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PTH1R purchase    MBS9357922 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor (PTH1R) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PTH1R. The ELISA analytical biochemical technique of the MBS9357922 kit is based on PTH1R antibody-PTH1R antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTH1R antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTH1R. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PTH1R. It may not necessarily be applicable to this product.
 NCBI GI #    296080761
 NCBI GeneID    5745
 NCBI Accession #    NP_001171673.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001184744.1 [Other Products]
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 UniProt Secondary Accession #    Q2M1U3 [Other Products]
 UniProt Related Accession #    Q03431 [Other Products]
 Molecular Weight    66,361 Da
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 NCBI Official Full Name    parathyroid hormone/parathyroid hormone-related peptide receptor
 NCBI Official Synonym Full Names    parathyroid hormone 1 receptor
 NCBI Official Symbol    PTH1R [Similar Products]
 NCBI Official Synonym Symbols   
PFE; PTHR; PTHR1
[Similar Products]
 NCBI Protein Information    parathyroid hormone/parathyroid hormone-related peptide receptor
 UniProt Protein Name    Parathyroid hormone/parathyroid hormone-related peptide receptor
 UniProt Synonym Protein Names   
PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor
 Protein Family    Parathyroid hormone/parathyroid hormone-related peptide receptor
 UniProt Gene Name    PTH1R [Similar Products]
 UniProt Synonym Gene Names    PTHR; PTHR1; PTH/PTHr receptor; PTH1 receptor [Similar Products]
 UniProt Entry Name    PTH1R_HUMAN
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 NCBI Summary for PTH1R    The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
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 UniProt Comments for PTH1R    PTHR: This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC). JMC is a rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones. Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD). BOCD is a severe skeletal dysplasia. Defects in PTH1R may be a cause of enchondromatosis multiple (ENCHOM). Enchondromas are common benign cartilage tumors of bone. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier and Maffucci diseases). Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma. Defects in PTH1R are the cause of Eiken skeletal dysplasia (EISD); also known as bone modeling defect of hands and feet. It is a rare familial autosomal recessive skeletal dysplasia. It is characterized by multiple epiphyseal dysplasia, with extremely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation. Defects in PTH1R are a cause of primary failure of tooth eruption (PFE). PFE is a rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2

Chromosomal Location of Human Ortholog: 3p22-p21.1

Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cytoplasm; cytosol; integral to plasma membrane; nucleus; plasma membrane; receptor complex

Molecular Function: parathyroid hormone receptor activity; peptide hormone binding; protein binding; protein self-association

Biological Process: aging; bone mineralization; bone resorption; cell maturation; cell surface receptor linked signal transduction; chondrocyte differentiation; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of cell proliferation; osteoblast development; positive regulation of cell proliferation; skeletal development

Disease: Chondrodysplasia, Blomstrand Type; Eiken Syndrome; Failure Of Tooth Eruption, Primary; Metaphyseal Chondrodysplasia, Jansen Type
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 Research Articles on PTH1R    1. This Review discusses current understanding of PTHR1 modes of action and how these findings might be applied in future therapeutic agents--{REVIEW}
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTH1R elisa kitPathways associated with PTH1R elisa kit
 Reference Product  PubMed Publications
 PTH elisa kit  >231 publications with PTH1R and PTH
 PTHLH elisa kit  >19 publications with PTH1R and PTHLH
 PTH2 elisa kit  >8 publications with PTH1R and PTH2
 ADRB2 elisa kit  >2 publications with PTH1R and ADRB2
 SLC9A3R1 elisa kit  >1 publications with PTH1R and SLC9A3R1
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with PTH1R elisa kitOrgans/Tissues associated with PTH1R elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >24 publications with PTH1R and Kidney Diseases
 Disease Models, Animal Antibodies  >17 publications with PTH1R and Disease Models, Animal
 Hyperparathyroidism Antibodies  >12 publications with PTH1R and Hyperparathyroidism
 Renal Insufficiency Antibodies  >10 publications with PTH1R and Renal Insufficiency
 Hypertrophy Antibodies  >10 publications with PTH1R and Hypertrophy
 Necrosis Antibodies  >8 publications with PTH1R and Necrosis
 Inflammation Antibodies  >8 publications with PTH1R and Inflammation
 Enchondromatosis Antibodies  >7 publications with PTH1R and Enchondromatosis
 Hyperplasia Antibodies  >4 publications with PTH1R and Hyperplasia
 Jansen type metaphyseal chondrodysplasia Antibodies  >4 publications with PTH1R and Jansen type metaphyseal chondrodysplasia
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >190 publications with PTH1R and Bone
 Kidney Antibodies  >55 publications with PTH1R and Kidney
 Connective Tissue Antibodies  >39 publications with PTH1R and Connective Tissue
 Muscle Antibodies  >22 publications with PTH1R and Muscle
 Embryonic Tissue Antibodies  >9 publications with PTH1R and Embryonic Tissue
 Heart Antibodies  >8 publications with PTH1R and Heart
 Brain Antibodies  >8 publications with PTH1R and Brain
 Nerve Antibodies  >6 publications with PTH1R and Nerve
 Lung Antibodies  >3 publications with PTH1R and Lung
 Placenta Antibodies  >2 publications with PTH1R and Placenta
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