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PDGF-alphaR elisa kit :: Bovine Platelet-derived growth factor-alpha receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS754016 PDGF-alphaR elisa kit
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Platelet-derived growth factor-alpha receptor (PDGF-alphaR), ELISA Kit

 Also Known As   

Bovine Platelet-derived growth factor-alpha receptor ELISA Kit

 Product Synonym Names    Bovine Platelet-derived growth factor-a receptor ELISA Kit
 Product Gene Name   

PDGF-alphaR elisa kit

[Similar Products]
 Product Synonym Gene Name    PDGF-aR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    607685
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 Species Reactivity    Bovine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PDGF-alphaR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PDGF-alphaR purchase    MBS754016 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Platelet-derived growth factor-alpha receptor (PDGF-alphaR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PDGF-alphaR. The ELISA analytical biochemical technique of the MBS754016 kit is based on PDGF-alphaR antibody-PDGF-alphaR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PDGF-alphaR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PDGF-alphaR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for PDGF-alphaR elisa kit    Cardiovascular
NCBI/Uniprot data below describe general gene information for PDGF-alphaR. It may not necessarily be applicable to this product.
 NCBI GI #    5453870
 NCBI GeneID    5156
 NCBI Accession #    NP_006197.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006206.4 [Other Products]
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 UniProt Secondary Accession #    Q6P4H5; Q96KZ7; Q9UD28; B2RE69; E9PBH0 [Other Products]
 UniProt Related Accession #    P16234 [Other Products]
 Molecular Weight    82,809 Da
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 NCBI Official Full Name    platelet-derived growth factor receptor alpha
 NCBI Official Synonym Full Names    platelet-derived growth factor receptor, alpha polypeptide
 NCBI Official Symbol    PDGFRA [Similar Products]
 NCBI Official Synonym Symbols   
CD140A; PDGFR2; PDGFR-2; RHEPDGFRA
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor receptor alpha; PDGF-R-alpha; CD140a antigen; PDGFRA/BCR fusion; CD140 antigen-like family member A; platelet-derived growth factor receptor 2; alpha-type platelet-derived growth factor receptor; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
 UniProt Protein Name    Platelet-derived growth factor receptor alpha
 UniProt Synonym Protein Names   
Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; PDGFR-2; CD_antigen: CD140a
 UniProt Gene Name    PDGFRA [Similar Products]
 UniProt Synonym Gene Names    PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2 [Similar Products]
 UniProt Entry Name    PGFRA_HUMAN
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 NCBI Summary for PDGF-alphaR    This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
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 UniProt Comments for PDGF-alphaR    PDGFRA: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; PDGFR family

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: microvillus; membrane; integral to plasma membrane; cytoplasm; plasma membrane; nucleus; intrinsic to plasma membrane; external side of plasma membrane

Molecular Function: vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; platelet-derived growth factor alpha-receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: estrogen metabolic process; extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of chemotaxis; viral reproduction; nerve growth factor receptor signaling pathway; wound healing; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; cardiac myofibril assembly; palate development; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; Leydig cell differentiation; embryonic digestive tract morphogenesis; luteinization; positive regulation of cell proliferation; male genitalia development; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; adrenal gland development; in utero embryonic development; positive regulation of phosphoinositide 3-kinase activity; embryonic cranial skeleton morphogenesis; odontogenesis of dentine-containing teeth; embryonic skeletal morphogenesis; positive regulation of phosphoinositide 3-kinase cascade; cell activation; innate immune response; hemopoietic progenitor cell differentiation; positive regulation of DNA replication; lung development; positive regulation of cell migration

Disease: Gastrointestinal Stromal Tumor; Hypereosinophilic Syndrome, Idiopathic
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 Research Articles on PDGF-alphaR    1. Our study suggests that patients with melanoma harboring certain PDGFRA mutations may benefit from imatinib and crenolanib treatment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDGF-alphaR elisa kitPathways associated with PDGF-alphaR elisa kit
 Reference Product  PubMed Publications
 PDGFRB elisa kit  >1640 publications with PDGF-alphaR and PDGFRB
 PDGFB elisa kit  >357 publications with PDGF-alphaR and PDGFB
 FGF2 elisa kit  >130 publications with PDGF-alphaR and FGF2
 PDGFA elisa kit  >43 publications with PDGF-alphaR and PDGFA
 GRB2 elisa kit  >13 publications with PDGF-alphaR and GRB2
 PDGFC elisa kit  >12 publications with PDGF-alphaR and PDGFC
 CRK elisa kit  >10 publications with PDGF-alphaR and CRK
 PIK3R1 elisa kit  >7 publications with PDGF-alphaR and PIK3R1
 CRKL elisa kit  >2 publications with PDGF-alphaR and CRKL
 PLCG1 elisa kit  >1 publications with PDGF-alphaR and PLCG1
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
Diseases associated with PDGF-alphaR elisa kitOrgans/Tissues associated with PDGF-alphaR elisa kit
 Disease Name  Pubmed Publications
 Gastrointestinal Stromal Tumors Antibodies  >696 publications with PDGF-alphaR and Gastrointestinal Stromal Tumors
 Fibrosis Antibodies  >266 publications with PDGF-alphaR and Fibrosis
 Hypereosinophilic Syndrome Antibodies  >261 publications with PDGF-alphaR and Hypereosinophilic Syndrome
 Necrosis Antibodies  >254 publications with PDGF-alphaR and Necrosis
 Cardiovascular Diseases Antibodies  >199 publications with PDGF-alphaR and Cardiovascular Diseases
 Skin Diseases Antibodies  >155 publications with PDGF-alphaR and Skin Diseases
 Lung Diseases Antibodies  >155 publications with PDGF-alphaR and Lung Diseases
 Inflammation Antibodies  >149 publications with PDGF-alphaR and Inflammation
 Liver Diseases Antibodies  >136 publications with PDGF-alphaR and Liver Diseases
 Kidney Diseases Antibodies  >109 publications with PDGF-alphaR and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >809 publications with PDGF-alphaR and Vascular
 Muscle Antibodies  >807 publications with PDGF-alphaR and Muscle
 Blood Antibodies  >636 publications with PDGF-alphaR and Blood
 Brain Antibodies  >445 publications with PDGF-alphaR and Brain
 Bone Antibodies  >356 publications with PDGF-alphaR and Bone
 Lung Antibodies  >289 publications with PDGF-alphaR and Lung
 Nerve Antibodies  >260 publications with PDGF-alphaR and Nerve
 Embryonic Tissue Antibodies  >253 publications with PDGF-alphaR and Embryonic Tissue
 Liver Antibodies  >243 publications with PDGF-alphaR and Liver
 Kidney Antibodies  >192 publications with PDGF-alphaR and Kidney
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