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CD59 elisa kit :: Bovine Protectin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS012733 CD59 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protectin (CD59), ELISA Kit

 Also Known As   

Bovine Protectin ELISA Kit

 Product Gene Name   

CD59 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    107271
 3D Structure    ModBase 3D Structure for P13987
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 Species Reactivity    Bovine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CD59 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CD59 purchase    MBS012733 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protectin (CD59) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CD59. The ELISA analytical biochemical technique of the MBS012733 kit is based on CD59 antibody-CD59 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CD59 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CD59. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CD59. It may not necessarily be applicable to this product.
 NCBI GI #    42716299
 NCBI GeneID    966
 NCBI Accession #    NP_976076.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_203331.2 [Other Products]
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 UniProt Primary Accession #    P13987 [Other Products]
 UniProt Related Accession #    P13987 [Other Products]
 Molecular Weight    14,177 Da
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 NCBI Official Full Name    CD59 glycoprotein preproprotein
 NCBI Official Synonym Full Names    CD59 molecule, complement regulatory protein
 NCBI Official Symbol    CD59 [Similar Products]
 NCBI Official Synonym Symbols   
1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
[Similar Products]
 NCBI Protein Information    CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
 UniProt Protein Name    CD59 glycoprotein
 UniProt Synonym Protein Names   
1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin
 Protein Family    CD59 glycoprotein
 UniProt Gene Name    CD59 [Similar Products]
 UniProt Synonym Gene Names    MIC11; MIN1; MIN2; MIN3; MSK21; HRF-20; HRF20; MAC-IP; MACIF; MIRL [Similar Products]
 UniProt Entry Name    CD59_HUMAN
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 NCBI Summary for CD59    This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD59    CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: anchored to external side of plasma membrane; extracellular space; compact myelin; focal adhesion; cell surface; membrane; plasma membrane; extracellular region; sarcolemma; vesicle

Molecular Function: complement binding; protein binding

Biological Process: cell activation; cell surface receptor linked signal transduction; regulation of complement activation; negative regulation of activation of membrane attack complex; innate immune response; positive regulation of T cell proliferation; blood coagulation; negative regulation of apoptosis

Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy
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 Research Articles on CD59    1. this study observed robust relationships between a single measurement of blood levels of GCD59 and both acute (2-hour OGTT) and chronic (HbA1c) measures of glucose handling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD59 elisa kitPathways associated with CD59 elisa kit
 Reference Product  PubMed Publications
 CD55 elisa kit  >800 publications with CD59 and CD55
 CD46 elisa kit  >312 publications with CD59 and CD46
 PIGA elisa kit  >23 publications with CD59 and PIGA
 CAV1 elisa kit  >5 publications with CD59 and CAV1
 C8A elisa kit  >1 publications with CD59 and C8A
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
Diseases associated with CD59 elisa kitOrgans/Tissues associated with CD59 elisa kit
 Disease Name  Pubmed Publications
 Anemia Antibodies  >395 publications with CD59 and Anemia
 Neoplasms Antibodies  >253 publications with CD59 and Neoplasms
 Inflammation Antibodies  >148 publications with CD59 and Inflammation
 Necrosis Antibodies  >77 publications with CD59 and Necrosis
 Disease Models, Animal Antibodies  >72 publications with CD59 and Disease Models, Animal
 Lymphoma Antibodies  >66 publications with CD59 and Lymphoma
 Kidney Diseases Antibodies  >50 publications with CD59 and Kidney Diseases
 Adenocarcinoma Antibodies  >36 publications with CD59 and Adenocarcinoma
 Brain Diseases Antibodies  >33 publications with CD59 and Brain Diseases
 Lung Diseases Antibodies  >30 publications with CD59 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >90 publications with CD59 and Heart
 Muscle Antibodies  >72 publications with CD59 and Muscle
 Brain Antibodies  >61 publications with CD59 and Brain
 Embryonic Tissue Antibodies  >44 publications with CD59 and Embryonic Tissue
 Skin Antibodies  >41 publications with CD59 and Skin
 Ovary Antibodies  >31 publications with CD59 and Ovary
 Placenta Antibodies  >20 publications with CD59 and Placenta
 Uterus Antibodies  >15 publications with CD59 and Uterus
 Pancreas Antibodies  >14 publications with CD59 and Pancreas
 Mammary Gland Antibodies  >2 publications with CD59 and Mammary Gland
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