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PT elisa kit :: Bovine Prothrombin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS014254 PT elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prothrombin (PT), ELISA Kit

 Also Known As   

Bovine Prothrombin ELISA Kit

 Product Gene Name   

PT elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 11; NC_000011.9 (46740743..46761056). Location: 11p11
 OMIM    176930
 3D Structure    ModBase 3D Structure for P00734
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 Species Reactivity    Bovine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PT purchase    MBS014254 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Prothrombin (PT) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PT. The ELISA analytical biochemical technique of the MBS014254 kit is based on PT antibody-PT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PT. It may not necessarily be applicable to this product.
 NCBI GI #    4503635
 NCBI GeneID    2147
 NCBI Accession #    NP_000497.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000506.3 [Other Products]
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 UniProt Primary Accession #    P00734 [Other Products]
 UniProt Secondary Accession #    Q4QZ40; Q53H04; Q53H06; Q7Z7P3; Q9UCA1; B2R7F7; B4E1A7 [Other Products]
 UniProt Related Accession #    P00734 [Other Products]
 Molecular Weight    70,037 Da
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 NCBI Official Full Name    prothrombin preproprotein
 NCBI Official Synonym Full Names    coagulation factor II (thrombin)
 NCBI Official Symbol    F2 [Similar Products]
 NCBI Official Synonym Symbols   
PT; THPH1; RPRGL2
[Similar Products]
 NCBI Protein Information    prothrombin; serine protease; prothrombin B-chain; prepro-coagulation factor II
 UniProt Protein Name    Prothrombin
 UniProt Synonym Protein Names   
Coagulation factor II
 Protein Family    Prothrombin
 UniProt Gene Name    F2 [Similar Products]
 UniProt Entry Name    THRB_HUMAN
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 NCBI Summary for PT    Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PT    prothrombin: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Defects in F2 are the cause of factor II deficiency (FA2D). It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1). It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2). A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.5; Secreted; Secreted, signal peptide; Apoptosis; Protease

Chromosomal Location of Human Ortholog: 11p11

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane

Molecular Function: protein binding; growth factor activity; serine-type endopeptidase activity; calcium ion binding; receptor binding

Biological Process: positive regulation of blood coagulation; multicellular organismal development; positive regulation of collagen biosynthetic process; proteolysis; regulation of cell shape; negative regulation of fibrinolysis; cell surface receptor linked signal transduction; positive regulation of cell proliferation; response to wounding; acute-phase response; negative regulation of proteolysis; platelet activation; cytosolic calcium ion homeostasis; post-translational protein modification; positive regulation of cell growth; peptidyl-glutamic acid carboxylation; positive regulation of phosphoinositide 3-kinase cascade; fibrinolysis; cellular protein metabolic process; regulation of gene expression; regulation of blood coagulation; negative regulation of astrocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; blood coagulation; blood coagulation, intrinsic pathway; leukocyte migration

Disease: Thrombophilia Due To Thrombin Defect; Stroke, Ischemic; Pregnancy Loss, Recurrent, Susceptibility To, 2; Prothrombin Deficiency, Congenital
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 Research Articles on PT    1. Letter: Plasmin and the thrombin-thrombomodulin complex both contribute to thrombin-activatable fibrinolysis inhibitor activation in whole blood model thrombi.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PT elisa kitPathways associated with PT elisa kit
 Reference Product  PubMed Publications
 FGA elisa kit  >8 publications with PT and FGA
 FGB elisa kit  >6 publications with PT and FGB
 FGG elisa kit  >5 publications with PT and FGG
 F2R elisa kit  >5 publications with PT and F2R
 GP1BA elisa kit  >5 publications with PT and GP1BA
 THBD elisa kit  >2 publications with PT and THBD
 SERPINC1 elisa kit  >1 publications with PT and SERPINC1
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with PT elisa kitOrgans/Tissues associated with PT elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1032 publications with PT and Nervous System Diseases
 Liver Diseases Antibodies  >706 publications with PT and Liver Diseases
 Neoplasms Antibodies  >680 publications with PT and Neoplasms
 Hypertension Antibodies  >659 publications with PT and Hypertension
 Drug Toxicity Antibodies  >616 publications with PT and Drug Toxicity
 Inflammation Antibodies  >526 publications with PT and Inflammation
 Liver Cirrhosis Antibodies  >468 publications with PT and Liver Cirrhosis
 Brain Diseases Antibodies  >455 publications with PT and Brain Diseases
 Heart Diseases Antibodies  >297 publications with PT and Heart Diseases
 Kidney Diseases Antibodies  >257 publications with PT and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1286 publications with PT and Liver
 Uterus Antibodies  >955 publications with PT and Uterus
 Kidney Antibodies  >719 publications with PT and Kidney
 Heart Antibodies  >680 publications with PT and Heart
 Embryonic Tissue Antibodies  >365 publications with PT and Embryonic Tissue
 Connective Tissue Antibodies  >251 publications with PT and Connective Tissue
 Spleen Antibodies  >231 publications with PT and Spleen
 Bone Marrow Antibodies  >105 publications with PT and Bone Marrow
 Mammary Gland Antibodies  >32 publications with PT and Mammary Gland
 Uncharacterized Tissue Antibodies  >2 publications with PT and Uncharacterized Tissue
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