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ARHGEF3 elisa kit :: Bovine Rho guanine nucleotide exchange factor 3 (ARHGEF3) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7227070 ARHGEF3 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rho guanine nucleotide exchange factor 3 (ARHGEF3), ELISA Kit

 Also Known As   

Bovine Rho guanine nucleotide exchange factor 3 (ARHGEF3) ELISA Kit

 Product Gene Name   

ARHGEF3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    612115
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ARHGEF3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ARHGEF3 purchase    MBS7227070 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Rho guanine nucleotide exchange factor 3 (ARHGEF3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ARHGEF3. The ELISA analytical biochemical technique of the MBS7227070 kit is based on ARHGEF3 antibody-ARHGEF3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ARHGEF3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ARHGEF3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for ARHGEF3 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for ARHGEF3. It may not necessarily be applicable to this product.
 NCBI GI #    9506401
 NCBI GeneID    50650
 NCBI Accession #    NP_062455.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019555.2 [Other Products]
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 UniProt Secondary Accession #    Q4FZB6; Q4QQI5; Q4QQQ0; Q59F00; Q6NUN3; Q7Z4U2; Q7Z5T2; Q9H7T4; A8K5U7 [Other Products]
 UniProt Related Accession #    Q9NR81 [Other Products]
 Molecular Weight    36,981 Da
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 NCBI Official Full Name    rho guanine nucleotide exchange factor 3 isoform 3
 NCBI Official Synonym Full Names    Rho guanine nucleotide exchange factor (GEF) 3
 NCBI Official Symbol    ARHGEF3 [Similar Products]
 NCBI Official Synonym Symbols   
GEF3; STA3; XPLN
[Similar Products]
 NCBI Protein Information    rho guanine nucleotide exchange factor 3; RhoGEF protein; 59.8 kDA protein; exchange factor found in platelets and leukemic and neuronal tissues, XPLN
 UniProt Protein Name    Rho guanine nucleotide exchange factor 3
 UniProt Synonym Protein Names   
Exchange factor found in platelets and leukemic and neuronal tissues; XPLN
 Protein Family    Rho guanine nucleotide exchange factor
 UniProt Gene Name    ARHGEF3 [Similar Products]
 UniProt Synonym Gene Names    XPLN [Similar Products]
 UniProt Entry Name    ARHG3_HUMAN
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 NCBI Summary for ARHGEF3    Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ARHGEF3    ARHGEF3: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: intracellular; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity

Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; Rho protein signal transduction
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 Research Articles on ARHGEF3    1. XPLN is an endogenous inhibitor of mTORC2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ARHGEF3 elisa kitDiseases associated with ARHGEF3 elisa kit
 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 Disease Name  Pubmed Publications
 Hematologic Diseases Antibodies  >2 publications with ARHGEF3 and Hematologic Diseases
 Anemia Antibodies  >2 publications with ARHGEF3 and Anemia
 Disease Models, Animal Antibodies  >1 publications with ARHGEF3 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with ARHGEF3 and Necrosis
Organs/Tissues associated with ARHGEF3 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >5 publications with ARHGEF3 and Bone
 Blood Antibodies  >3 publications with ARHGEF3 and Blood
 Muscle Antibodies  >2 publications with ARHGEF3 and Muscle
 Kidney Antibodies  >2 publications with ARHGEF3 and Kidney
 Brain Antibodies  >2 publications with ARHGEF3 and Brain
 Prostate Antibodies  >1 publications with ARHGEF3 and Prostate
 Parathyroid Antibodies  >1 publications with ARHGEF3 and Parathyroid
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