NP_598278.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,871 Da
NCBI Official Full Name
small ubiquitin-related modifier 2
NCBI Official Synonym Full Names
small ubiquitin-like modifier 2
NCBI Protein Information
small ubiquitin-related modifier 2; SUMO-2; sentrin-2; SMT3 homolog 2; ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B; SMT3 suppressor of mif two 3 homolog 2
UniProt Protein Name
Small ubiquitin-related modifier 2
UniProt Synonym Protein Names
SMT3 homolog 2; Sentrin-2; Ubiquitin-like protein SMT3A; Smt3A
UniProt Synonym Gene Names
UniProt Entry Name
SUMO2_RAT
NCBI Summary for SUMO2
LDH isozyme which show evolutionary relationships among vertebrate [RGD, Feb 2006]
UniProt Comments for SUMO2
SUMO2: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Broadly expressed. Belongs to the ubiquitin family. SUMO subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin-like modifier
Cellular Component: PML body; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding; SUMO ligase activity
Biological Process: protein sumoylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on SUMO2
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Pathways associated with SUMO2 elisa kit
Diseases associated with SUMO2 elisa kit
Organs/Tissues associated with SUMO2 elisa kit
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