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ATP1A2 elisa kit :: Bovine Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7218608 ATP1A2 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2), ELISA Kit

 Also Known As   

Bovine Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) ELISA Kit

 Product Gene Name   

ATP1A2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 602481
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 Species Reactivity    Bovine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ATP1A2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ATP1A2 purchase    MBS7218608 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATP1A2. The ELISA analytical biochemical technique of the MBS7218608 kit is based on ATP1A2 antibody-ATP1A2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATP1A2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATP1A2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for ATP1A2 elisa kit    Neuroscience
NCBI/Uniprot data below describe general gene information for ATP1A2. It may not necessarily be applicable to this product.
 NCBI GI #    4502271
 NCBI GeneID    477
 NCBI Accession #    NP_000693.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000702.3 [Other Products]
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 UniProt Secondary Accession #    Q07059; Q5JW74; Q86UZ5; Q9UQ25; D3DVE4 [Other Products]
 UniProt Related Accession #    P50993 [Other Products]
 Molecular Weight    112,265 Da
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 NCBI Official Full Name    sodium/potassium-transporting ATPase subunit alpha-2 proprotein
 NCBI Official Synonym Full Names    ATPase, Na+/K+ transporting, alpha 2 polypeptide
 NCBI Official Symbol    ATP1A2 [Similar Products]
 NCBI Official Synonym Symbols   
FHM2; MHP2
[Similar Products]
 NCBI Protein Information    sodium/potassium-transporting ATPase subunit alpha-2; sodium pump subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; sodium-potassium ATPase catalytic subunit alpha-2; sodium/potassium-transporting ATPase alpha-2 chain
 UniProt Protein Name    Sodium/potassium-transporting ATPase subunit alpha-2
 UniProt Synonym Protein Names   
Sodium pump subunit alpha-2
 Protein Family    Sodium/potassium-transporting ATPase
 UniProt Gene Name    ATP1A2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0778; Na(+)/K(+) ATPase alpha-2 subunit [Similar Products]
 UniProt Entry Name    AT1A2_HUMAN
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 NCBI Summary for ATP1A2    The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ATP1A2    ATP1A2: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. Defects in ATP1A2 are the cause of familial hemiplegic migraine type 2 (FHM2). FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. Defects in ATP1A2 are a cause of alternating hemiplegia of childhood 1 (AHC1). AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; EC 3.6.3.9

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: cytoplasm; T-tubule; dendritic spine; plasma membrane; synapse; caveola; sodium:potassium-exchanging ATPase complex; vesicle; endosome

Molecular Function: metal ion binding; chaperone binding; sodium:potassium-exchanging ATPase activity; ATP binding

Biological Process: response to nicotine; regulation of smooth muscle contraction; cellular sodium ion homeostasis; negative regulation of heart contraction; metabolic process; adult locomotory behavior; regulation of striated muscle contraction; sodium ion transport; neurological control of breathing; cellular potassium ion homeostasis; negative regulation of striated muscle contraction; potassium ion import; regulation of blood pressure; reduction of cytosolic calcium ion concentration; regulation of vasoconstriction; ATP hydrolysis coupled proton transport; neurotransmitter uptake; visual learning; locomotion; transmembrane transport; potassium ion transport; regulation of the force of heart contraction; cardiac muscle contraction

Disease: Migraine, Familial Hemiplegic, 2; Alternating Hemiplegia Of Childhood 1
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 Research Articles on ATP1A2    1. In this family, benign familial infantile seizures (BFIS) are caused by a PRRT2 mutation and hemiplegic migraine by p.Arg689Gln ATPase ATP1A2 mutation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATP1A2 elisa kitPathways associated with ATP1A2 elisa kit
 Reference Product  PubMed Publications
 CACNA1A elisa kit  >90 publications with ATP1A2 and CACNA1A
 SCN1A elisa kit  >45 publications with ATP1A2 and SCN1A
 ATP1A1 elisa kit  >36 publications with ATP1A2 and ATP1A1
 ATP1A3 elisa kit  >16 publications with ATP1A2 and ATP1A3
 ATP1B1 elisa kit  >8 publications with ATP1A2 and ATP1B1
 ATP1A4 elisa kit  >5 publications with ATP1A2 and ATP1A4
 KCNK18 elisa kit  >3 publications with ATP1A2 and KCNK18
 ATP1B3 elisa kit  >3 publications with ATP1A2 and ATP1B3
 ATP1B2 elisa kit  >3 publications with ATP1A2 and ATP1B2
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
Diseases associated with ATP1A2 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >147 publications with ATP1A2 and Nervous System Diseases
 Brain Diseases Antibodies  >136 publications with ATP1A2 and Brain Diseases
 Seizures Antibodies  >26 publications with ATP1A2 and Seizures
 Cardiovascular Diseases Antibodies  >25 publications with ATP1A2 and Cardiovascular Diseases
 Hypertension Antibodies  >20 publications with ATP1A2 and Hypertension
 Disease Models, Animal Antibodies  >19 publications with ATP1A2 and Disease Models, Animal
 Ataxia Antibodies  >18 publications with ATP1A2 and Ataxia
 Mental Disorders Antibodies  >13 publications with ATP1A2 and Mental Disorders
 Heart Diseases Antibodies  >11 publications with ATP1A2 and Heart Diseases
 Edema Antibodies  >9 publications with ATP1A2 and Edema
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