NP_001057.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,461 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 1B
NCBI Official Synonym Full Names
TNF receptor superfamily member 1B
NCBI Official Synonym Symbols
p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 1B
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 1B
UniProt Synonym Protein Names
Tumor necrosis factor receptor 2; TNF-R2
UniProt Synonym Gene Names
UniProt Entry Name
TNR1B_HUMAN
NCBI Summary for TNF-RII
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
UniProt Comments for TNF-RII
TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: integral to plasma membrane; lipid raft; plasma membrane
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: immune response; inflammatory response; multicellular organismal development; positive regulation of MAPKKK cascade; positive regulation of membrane protein ectodomain proteolysis; regulation of apoptosis; regulation of cell proliferation; tumor necrosis factor-mediated signaling pathway
Research Articles on TNF-RII
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Products associated with TNF-RII elisa kit
Pathways associated with TNF-RII elisa kit
Diseases associated with TNF-RII elisa kit
Organs/Tissues associated with TNF-RII elisa kit
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