NP_004647.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,362 Da
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase BAP1
NCBI Official Synonym Full Names
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase BAP1; cerebral protein 6; cerebral protein-13
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase BAP1
UniProt Synonym Protein Names
BRCA1-associated protein 1; Cerebral protein 6
UniProt Synonym Gene Names
UniProt Entry Name
BAP1_HUMAN
NCBI Summary for BAP1
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
UniProt Comments for BAP1
BAP1: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Highly expressed in testis, placenta and ovary. Expressed in breast. Belongs to the peptidase C12 family. BAP1 subfamily.
Protein type: Ubiquitin-specific protease; Protease; Tumor suppressor; Ubiquitin conjugating system; EC 3.4.19.12
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: peptidase activity; protein binding; ubiquitin-specific protease activity; chromatin binding
Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; protein deubiquitination; regulation of cell cycle; protein modification process; regulation of cell growth
Disease: Tumor Predisposition Syndrome
Research Articles on BAP1
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Products associated with BAP1 elisa kit
Diseases associated with BAP1 elisa kit
Organs/Tissues associated with BAP1 elisa kit
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