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VGCC elisa kit :: Bovine Voltage-gated calcium channel ELISA Kit

Scan QR to view Datasheet Catalog #    MBS743198 VGCC elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Voltage-gated calcium channel (VGCC), ELISA Kit

 Also Known As   

Bovine Voltage-gated calcium channel ELISA Kit

 Product Gene Name   

VGCC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    611875
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of VGCC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for VGCC purchase    MBS743198 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Voltage-gated calcium channel (VGCC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing VGCC. The ELISA analytical biochemical technique of the MBS743198 kit is based on VGCC antibody-VGCC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VGCC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VGCC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for VGCC elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for VGCC. It may not necessarily be applicable to this product.
 NCBI GI #    951207
 NCBI GeneID    775
 NCBI Accession #    AAA74590.1 [Other Products]
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 UniProt Secondary Accession #    Q13917; Q13918; Q13919; Q13920; Q13921; Q13922; Q13923; Q13924; Q13925; B2RUT3; E9PDJ0 [Other Products]
 UniProt Related Accession #    Q13936 [Other Products]
 Molecular Weight    239,704 Da
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 NCBI Official Full Name    voltage-gated calcium channel, partial
 NCBI Official Synonym Full Names    calcium channel, voltage-dependent, L type, alpha 1C subunit
 NCBI Official Symbol    CACNA1C [Similar Products]
 NCBI Official Synonym Symbols   
TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
[Similar Products]
 NCBI Protein Information    voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; voltage-dependent L-type Ca2+ channel alpha 1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
 UniProt Protein Name    Voltage-dependent L-type calcium channel subunit alpha-1C
 UniProt Synonym Protein Names   
Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2
 UniProt Gene Name    CACNA1C [Similar Products]
 UniProt Synonym Gene Names    CACH2; CACN2; CACNL1A1; CCHL1A1 [Similar Products]
 UniProt Entry Name    CAC1C_HUMAN
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 NCBI Summary for VGCC    This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
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 UniProt Comments for VGCC    CACNA1C: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function. Defects in CACNA1C are the cause of Timothy syndrome (TS). TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism. Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. 35 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cell soma; cytoplasm; postsynaptic density; integral to membrane; caveolar macromolecular signaling complex; plasma membrane; voltage-gated calcium channel complex; dendritic shaft; Z disc

Molecular Function: calmodulin binding; voltage-gated calcium channel activity; protein binding; enzyme binding; metal ion binding; high voltage-gated calcium channel activity; alpha-actinin binding

Biological Process: synaptic transmission; growth hormone secretion; axon guidance; elevation of cytosolic calcium ion concentration; smooth muscle contraction involved in micturition; insulin secretion; regulation of blood pressure; regulation of vasoconstriction; energy reserve metabolic process; visual learning; regulation of organ growth; glucose homeostasis; adult walking behavior; regulation of insulin secretion; calcium ion-dependent exocytosis

Disease: Timothy Syndrome; Brugada Syndrome 3
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 Research Articles on VGCC    1. The rs1006737 and rs4765905 markers in CACNA1C, significant differences in the allele frequencies were found between the patients and controls in Han Chinese.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with VGCC elisa kitDiseases associated with VGCC elisa kit
 Products by Pathway  Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Disease Name  Pubmed Publications
 Bipolar Disorder Antibodies  >79 publications with VGCC and Bipolar Disorder
 Cardiovascular Diseases Antibodies  >62 publications with VGCC and Cardiovascular Diseases
 Heart Diseases Antibodies  >55 publications with VGCC and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >52 publications with VGCC and Arrhythmias, Cardiac
 Timothy syndrome Antibodies  >26 publications with VGCC and Timothy syndrome
 Nervous System Diseases Antibodies  >25 publications with VGCC and Nervous System Diseases
 Hypertension Antibodies  >13 publications with VGCC and Hypertension
 Limb Deformities, Congenital Antibodies  >11 publications with VGCC and Limb Deformities, Congenital
 Atrial Fibrillation Antibodies  >8 publications with VGCC and Atrial Fibrillation
 Brugada Syndrome 3 Antibodies  >7 publications with VGCC and Brugada Syndrome 3
Organs/Tissues associated with VGCC elisa kit
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >72 publications with VGCC and Heart
 Brain Antibodies  >65 publications with VGCC and Brain
 Lung Antibodies  >8 publications with VGCC and Lung
 Liver Antibodies  >5 publications with VGCC and Liver
 Intestine Antibodies  >4 publications with VGCC and Intestine
 Eye Antibodies  >3 publications with VGCC and Eye
 Ovary Antibodies  >3 publications with VGCC and Ovary
 Pancreas Antibodies  >2 publications with VGCC and Pancreas
 Ganglia Antibodies  >1 publications with VGCC and Ganglia
 Embryonic Tissue Antibodies  >1 publications with VGCC and Embryonic Tissue
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