NP_001094392.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,879 Da
NCBI Official Full Name
cAMP-dependent protein kinase catalytic subunit alpha
NCBI Official Synonym Full Names
protein kinase cAMP-activated catalytic subunit alpha
NCBI Protein Information
cAMP-dependent protein kinase catalytic subunit alpha
UniProt Protein Name
cAMP-dependent protein kinase catalytic subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
KAPCA_RAT
NCBI Summary for PRKACA
active catalytic subunit of protein kinase A; phosphorylates and activates transcription factors in response to elevated levels of cAMP; mediates phosphorylation and regulation of enzyme substrates involved in intermediary metabolism [RGD, Feb 2006]
UniProt Comments for PRKACA
PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.
Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.11; Protein kinase, Ser/Thr (non-receptor); AGC group; PKA family
Cellular Component: AMP-activated protein kinase complex; cAMP-dependent protein kinase complex; centrosome; cytoplasm; cytosol; Golgi apparatus; membrane; mitochondrion; neuromuscular junction; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex
Molecular Function: ATP binding; cAMP-dependent protein kinase activity; protein binding; protein complex binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; Rab GTPase binding; ubiquitin protein ligase binding
Biological Process: mesoderm formation; negative regulation of meiotic cell cycle; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell proliferation; positive regulation of protein export from nucleus; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cellular respiration; regulation of osteoblast differentiation; regulation of synaptic transmission; regulation of synaptic transmission, glutamatergic; sperm capacitation
Research Articles on PRKACA
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Products associated with PRKACA elisa kit
Pathways associated with PRKACA elisa kit
Organs/Tissues associated with PRKACA elisa kit
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