NP_776464.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
88,369 Da
NCBI Official Full Name
dipeptidyl peptidase 4
NCBI Official Synonym Symbols
NCBI Protein Information
dipeptidyl peptidase 4; ACT3; WC10; ADCP-I; DPP IV; activation molecule 3; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
UniProt Protein Name
Dipeptidyl peptidase 4
UniProt Synonym Protein Names
Activation molecule 3; ACT3; Adenosine deaminase complexing protein; ADCP-I; Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; WC10; CD_antigen: CD26Cleaved into the following 2 chains:Dipeptidyl peptidase 4 membrane formAlternative name(s):Dipeptidyl peptidase IV membrane form
UniProt Synonym Gene Names
UniProt Entry Name
DPP4_BOVIN
UniProt Comments for DPP4
Function: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline
Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Enzyme regulation: Inhibited by GPC3 and diprotin A
Research Articles on DPP4
Precautions
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Disclaimer
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Pathways associated with DPP4 elisa kit
Products by Pathway |
Pathway Diagram |
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies |
Incretin Synthesis, Secretion, And Inactivation Pathway Diagram |
Metabolism Of Proteins Pathway antibodies |
Metabolism Of Proteins Pathway Diagram |
Peptide Hormone Metabolism Pathway antibodies |
Peptide Hormone Metabolism Pathway Diagram |
Protein Digestion And Absorption Pathway antibodies |
Protein Digestion And Absorption Pathway Diagram |
Protein Digestion And Absorption Pathway antibodies |
Protein Digestion And Absorption Pathway Diagram |
Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies |
Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram |
Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies |
Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram |
Diseases associated with DPP4 elisa kit
Organs/Tissues associated with DPP4 elisa kit
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