NP_001287786.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,560 Da
NCBI Official Full Name
fos-related antigen 1 isoform 5
NCBI Official Synonym Full Names
FOS like 1, AP-1 transcription factor subunit
NCBI Protein Information
fos-related antigen 1
UniProt Protein Name
Fos-related antigen 1
UniProt Synonym Gene Names
UniProt Entry Name
FOSL1_HUMAN
NCBI Summary for FRA
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Comments for FRA
FRA1: an oncogenic transcription factor of the bZIP family, Fos subfamily. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate but short-lived, while FRA1 and FRA2 expression persists longer. FRA1 is involved in cell motility, invasiveness, and inhibits apoptosis. Elevated in many cancers and associated with tumorigenesis and cancer progression. Involved in Erk2-mediated Epithelial-to-Mesenchymal Transition (EMT) pathway. ERK2/FRA2 regulate ZEB1/2 expression, known to be associated with the EMT. Smad2/3-Fra1 complexes may reflect activation of the Smad/AP-1-dependent TGF¿-induced breast cancer invasion program. Activation of FRA1/C-JUN by ERK/AKT pathways can induce EZH2 overexpression, silencing integrin alpha-2 expression, and increasing the metastatic potential of colorectal cancer. Belongs to the bZIP family. Fos subfamily.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: cellular defense response; chemotaxis; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; response to virus; transcription from RNA polymerase II promoter
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Products associated with FRA elisa kit
Pathways associated with FRA elisa kit
Diseases associated with FRA elisa kit
Organs/Tissues associated with FRA elisa kit
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