P04921.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,910 Da
NCBI Official Full Name
Glycophorin-C
NCBI Official Synonym Full Names
glycophorin C (Gerbich blood group)
NCBI Official Synonym Symbols
GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2' [Similar Products]
NCBI Protein Information
glycophorin-C
UniProt Protein Name
Glycophorin-C
UniProt Synonym Protein Names
Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD_antigen: CD236
UniProt Synonym Gene Names
UniProt Entry Name
GLPC_HUMAN
NCBI Summary for GS-ANA
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
UniProt Comments for GS-ANA
GYPC: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. Belongs to the glycophorin-C family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q14-q21
Cellular Component: cortical cytoskeleton; integral to plasma membrane; membrane
Molecular Function: protein binding
Disease: Blood Group, Gerbich System; Malaria, Susceptibility To
Research Articles on GS-ANA
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