NP_001069744.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,665 Da
NCBI Official Full Name
myristoylated alanine-rich C-kinase substrate
NCBI Official Synonym Full Names
myristoylated alanine-rich protein kinase C substrate<
NCBI Protein Information
myristoylated alanine-rich C-kinase substrate; ACAMP-81
UniProt Protein Name
Myristoylated alanine-rich C-kinase substrate
UniProt Synonym Protein Names
ACAMP-81
UniProt Synonym Gene Names
UniProt Entry Name
MARCS_BOVIN
UniProt Comments for MARCKS
MARCKS: the most prominent cellular substrate of protein kinase C. Binds calmodulin, actin, and synapsin. A filamentous actin cross-linking protein. Critical for normal brain development. Phosphorylation by PKC displaces it from the plasma membrane, inhibiting F-actin cross-linking activity. Plays a role in growth cone adhesion: its nonphosphorylated form stabilizes integrin-mediated adhesions, and its phosphorylation-triggered release from adhesions causes localized growth cone detachment. Highly expressed in immature T and B lymphocytes: its expression is highest in CD4-8- T cells and B-cell blasts generated by antigen receptor signaling. Its expression and phosphorylation are closely linked to microglial activation processes involved in pathological conditions such as neuroinflammation and neurodegeneration.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Cellular Component: cytoplasm; plasma membrane
Molecular Function: calmodulin binding; actin binding
Research Articles on MARCKS
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Products associated with MARCKS elisa kit
Pathways associated with MARCKS elisa kit
Diseases associated with MARCKS elisa kit
Organs/Tissues associated with MARCKS elisa kit
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