NP_001039729.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
47,846 Da
NCBI Official Full Name
histone-lysine N-methyltransferase SUV39H1
NCBI Official Synonym Full Names
suppressor of variegation 3-9 homolog 1 (Drosophila)<
NCBI Protein Information
histone-lysine N-methyltransferase SUV39H1; su(var)3-9 homolog 1
UniProt Protein Name
Histone-lysine N-methyltransferase SUV39H1
UniProt Synonym Protein Names
Suppressor of variegation 3-9 homolog 1; Su(var)3-9 homolog 1
UniProt Synonym Gene Names
UniProt Entry Name
SUV91_BOVIN
UniProt Comments for SUV39H1
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation
Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Enzyme regulation: Negatively regulated by CCAR2
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Pathways associated with SUV39H1 elisa kit
Diseases associated with SUV39H1 elisa kit
Organs/Tissues associated with SUV39H1 elisa kit
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