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CRP elisa kit

Scan QR to view Datasheet Catalog #    MBS564066 CRP elisa kit
Unit / Price
1x96 Wells  /  $480 +1 FREE 8GB USB
 
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 Product Name   

CRP, ELISA Kit

★Popular Item★
 Also Known As   

Mouse CRP ELISA Kit

 Product Gene Name   

CRP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (159682079..159684379, complement). Location: 1q21-q23
 OMIM    123260
 3D Structure    ModBase 3D Structure for P02741
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 Host    Mouse
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 Samples    Immunoperoxidase Assay for Determination of C - REACTIVE PROTEIN in Mouse Samples
 Assay Type    Sandwich
 Intended Uses    The CRP test kits are a highly sensitive two-site enzyme linked immunoassay (ELISA) for measuring CRP in biological samples of mice.
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 Preparation and Storage    Store at 4 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CRP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CRP purchase    MBS564066 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Mouse CRP, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CRP. The ELISA analytical biochemical technique of the MBS564066 kit is based on CRP antibody-CRP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CRP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CRP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Immunoperoxidase Assay for Determination of C - REACTIVE PROTEIN in Mouse Samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for CRP elisa kit

   Principle of the Assay: The principle of the double antibody sandwich ELISA is represented in Figure 1. In this assay the CRP present in samples reacts with the anti-CRP antibodies which have been adsorbed to the surface of polystyrene microtitre wells. After the removal of unbound proteins by washing, anti-CRP antibodies conjugated with horseradish peroxidase (HRP), are added. These enzyme-labeled antibodies form complexes with the previously bound CRP. Following another washing step, the enzyme bound to the immunosorbent is assayed by the addition of a chromogenic substrate, 3,3',5,5'-tetramethylbenzidine (TMB). The quantity of bound enzyme varies directly with the concentration of CRP in the sample tested; thus, the absorbance, at 450 nm, is a measure of the concentration of CRP in the test sample. The quantity of CRP in the test sample can be interpolated from the standard curve constructed from the standards, and corrected for sample dilution.

Background: Acute phase proteins are plasma proteins which increase in concentration following infection, inflammation or trauma. The first acute phase protein to be recognized was discovered in humans by Tillet and Frances in 19301. This C-reactive protein (CRP) is so named because it is able to effect precipitation of somatic C-polysaccharide of Streptococcus pneumonia. CRP is an alpha globulin with a mass of 110,000 to 140,000 daltons, and composed of five identical subunits, which are non-covalently assembled as a cyclic pentamer. It is synthesized in the liver and, in humans, is normally present as a trace constituent of serum at levels less that 0.3 mG/dL. The levels in serum rise quickly following acute tissue damage and also falls very rapidly once the stimulus is removed. It has been proposed that the function of CRP is to aid in complement activation, influence phagocytic cell function, and augment cell mediated cytotoxicity. Investigations over the past few years have shown that quantification of these in plasma or serum can provide valuable diagnostic information in the detection, prognosis, and monitoring of disease not only in humans, but in companion animals and farm herds as well2.
 Product Categories/Family for CRP elisa kit    ELISA Kit
Sample Manual Insert of MBS564066. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CRP. It may not necessarily be applicable to this product.
 NCBI GI #    17975775
 NCBI GeneID    1401
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 UniProt Primary Accession #    P02741 [Other Products]
 UniProt Secondary Accession #    Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0 [Other Products]
 UniProt Related Accession #    P02741; Q5VVP7 [Other Products]
 Molecular Weight    25,039 Da [Similar Products]
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 NCBI Official Full Name    CRP
 NCBI Official Synonym Full Names    C-reactive protein, pentraxin-related
 NCBI Official Symbol    CRP [Similar Products]
 NCBI Official Synonym Symbols   
PTX1; MGC88244; MGC149895
[Similar Products]
 NCBI Protein Information    C-reactive protein; pentraxin 1; OTTHUMP00000033307
 UniProt Protein Name    C-reactive protein
 Protein Family    Cryparin
 UniProt Gene Name    CRP [Similar Products]
 UniProt Synonym Gene Names    PTX1 [Similar Products]
 UniProt Entry Name    CRP_HUMAN
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 NCBI Summary for CRP    The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]
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 UniProt Comments for CRP    CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular space; growth cone; extracellular region; filopodium

Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; cholesterol binding; virion binding; low-density lipoprotein binding; calcium ion binding

Biological Process: protein polymerization; defense response to Gram-positive bacterium; response to ethanol; wound healing; negative regulation of vasodilation; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging
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 Research Articles on CRP    1. Findings indicate that IL-6 is a powerful independent predictor of future CV events in high-risk Japanese patients, suggesting its predictive value is superior to hs-CRP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CRP elisa kitPathways associated with CRP elisa kit
 Reference Product  PubMed Publications
 CFH elisa kit  >16 publications with CRP and CFH
 APCS elisa kit  >6 publications with CRP and APCS
 FCGR2A elisa kit  >5 publications with CRP and FCGR2A
 FCGR1A elisa kit  >5 publications with CRP and FCGR1A
 LEP elisa kit  >3 publications with CRP and LEP
 FCGR2B elisa kit  >3 publications with CRP and FCGR2B
 GP6 elisa kit  >2 publications with CRP and GP6
 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immunity Signaling Pathway antibodies  Innate Immunity Signaling Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
Diseases associated with CRP elisa kitOrgans/Tissues associated with CRP elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7583 publications with CRP and Inflammation
 Cardiovascular Diseases Antibodies  >6047 publications with CRP and Cardiovascular Diseases
 Heart Diseases Antibodies  >2949 publications with CRP and Heart Diseases
 Myocardial Ischemia Antibodies  >2438 publications with CRP and Myocardial Ischemia
 Coronary Disease Antibodies  >2198 publications with CRP and Coronary Disease
 Autoimmune Diseases Antibodies  >1763 publications with CRP and Autoimmune Diseases
 Arteriosclerosis Antibodies  >1560 publications with CRP and Arteriosclerosis
 Diabetes Mellitus Antibodies  >1330 publications with CRP and Diabetes Mellitus
 Insulin Resistance Antibodies  >1267 publications with CRP and Insulin Resistance
 Obesity Antibodies  >1201 publications with CRP and Obesity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13407 publications with CRP and Blood
 Liver Antibodies  >947 publications with CRP and Liver
 Muscle Antibodies  >834 publications with CRP and Muscle
 Lung Antibodies  >710 publications with CRP and Lung
 Brain Antibodies  >607 publications with CRP and Brain
 Pancreas Antibodies  >111 publications with CRP and Pancreas
 Placenta Antibodies  >36 publications with CRP and Placenta
 Bladder Antibodies  >36 publications with CRP and Bladder
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