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ATM elisa kit :: Camel Ataxia Telangiectasia Mutated ELISA Kit

Scan QR to view Datasheet Catalog #    MBS048429 ATM elisa kit
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ataxia Telangiectasia Mutated (ATM), ELISA Kit

 Also Known As   

Camel Ataxia Telangiectasia Mutated ELISA Kit

 Product Gene Name   

ATM elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 11; NC_000011.9 (108093559..108239826). Location: 11q22-q23
 OMIM    208900
 3D Structure    ModBase 3D Structure for Q13315
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 Species Reactivity    Camel
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ATM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ATM purchase    MBS048429 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ataxia Telangiectasia Mutated (ATM) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATM. The ELISA analytical biochemical technique of the MBS048429 kit is based on ATM antibody-ATM antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATM antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATM. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ATM. It may not necessarily be applicable to this product.
 NCBI GI #    187951615
 NCBI GeneID    472
 NCBI Accession #    AAI37170.1 [Other Products]
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 UniProt Primary Accession #    Q13315 [Other Products]
 UniProt Secondary Accession #    O15429; Q12758; Q16551; Q93007; Q9NP02; Q9UCX7; B2RNX5 [Other Products]
 UniProt Related Accession #    Q13315 [Other Products]
 Molecular Weight    350,714 Da
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 NCBI Official Full Name    Ataxia telangiectasia mutated
 NCBI Official Synonym Full Names    ataxia telangiectasia mutated
 NCBI Official Symbol    ATM [Similar Products]
 NCBI Official Synonym Symbols   
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
[Similar Products]
 NCBI Protein Information    serine-protein kinase ATM; AT mutated; A-T mutated; TEL1, telomere maintenance 1, homolog
 UniProt Protein Name    Serine-protein kinase ATM
 UniProt Synonym Protein Names   
Ataxia telangiectasia mutated
 Protein Family    Serine-protein kinase
 UniProt Gene Name    ATM [Similar Products]
 UniProt Synonym Gene Names    A-T mutated [Similar Products]
 UniProt Entry Name    ATM_HUMAN
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 NCBI Summary for ATM    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
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 UniProt Comments for ATM    ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.

Protein type: DNA repair, damage; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor; Kinase, protein; ATYPICAL group; PIKK family

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasmic membrane-bound vesicle; spindle

Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; 1-phosphatidylinositol-3-kinase activity; protein complex binding; DNA-dependent protein kinase activity; protein N-terminus binding; histone serine kinase activity; ATP binding

Biological Process: lipoprotein catabolic process; DNA damage induced protein phosphorylation; positive regulation of apoptosis; heart development; protein amino acid autophosphorylation; pre-B cell allelic exclusion; negative regulation of B cell proliferation; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein amino acid phosphorylation; positive regulation of neuron apoptosis; double-strand break repair; mitotic cell cycle spindle assembly checkpoint; cell cycle arrest; telomere maintenance; somitogenesis; V(D)J recombination; DNA repair; double-strand break repair via homologous recombination; neuron apoptosis; peptidyl-serine phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; meiotic recombination; response to hypoxia; response to ionizing radiation; brain development; positive regulation of DNA damage response, signal transduction by p53 class mediator; response to DNA damage stimulus; oocyte development

Disease: Ataxia-telangiectasia; Breast Cancer
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 Research Articles on ATM    1. ATM is active in cell signalling pathways involved in maintaining cellular homeostasis. [Review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATM elisa kitPathways associated with ATM elisa kit
 Reference Product  PubMed Publications
 BRCA1 elisa kit  >415 publications with ATM and BRCA1
 H2AFX elisa kit  >287 publications with ATM and H2AFX
 TP53 elisa kit  >267 publications with ATM and TP53
 MRE11A elisa kit  >150 publications with ATM and MRE11A
 TP53BP1 elisa kit  >88 publications with ATM and TP53BP1
 CHEK2 elisa kit  >70 publications with ATM and CHEK2
 RAD17 elisa kit  >54 publications with ATM and RAD17
 KAT5 elisa kit  >21 publications with ATM and KAT5
 CHEK1 elisa kit  >11 publications with ATM and CHEK1
 ABL1 elisa kit  >1 publications with ATM and ABL1
 Products by Pathway  Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway antibodies  Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
Diseases associated with ATM elisa kitOrgans/Tissues associated with ATM elisa kit
 Disease Name  Pubmed Publications
 Ataxia Telangiectasia Antibodies  >3253 publications with ATM and Ataxia Telangiectasia
 Neoplasms Antibodies  >1708 publications with ATM and Neoplasms
 Nervous System Diseases Antibodies  >1345 publications with ATM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1173 publications with ATM and Cardiovascular Diseases
 Brain Diseases Antibodies  >1148 publications with ATM and Brain Diseases
 Chromosome Aberrations Antibodies  >395 publications with ATM and Chromosome Aberrations
 Breast Neoplasms Antibodies  >379 publications with ATM and Breast Neoplasms
 Heart Diseases Antibodies  >283 publications with ATM and Heart Diseases
 Disease Models, Animal Antibodies  >256 publications with ATM and Disease Models, Animal
 Drug Toxicity Antibodies  >224 publications with ATM and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1208 publications with ATM and Blood
 Brain Antibodies  >668 publications with ATM and Brain
 Vascular Antibodies  >461 publications with ATM and Vascular
 Lung Antibodies  >406 publications with ATM and Lung
 Heart Antibodies  >275 publications with ATM and Heart
 Muscle Antibodies  >215 publications with ATM and Muscle
 Skin Antibodies  >166 publications with ATM and Skin
 Liver Antibodies  >157 publications with ATM and Liver
 Kidney Antibodies  >151 publications with ATM and Kidney
 Nerve Antibodies  >144 publications with ATM and Nerve
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