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CX26 elisa kit :: Camel Connexin 26 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS108777 CX26 elisa kit
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 Product Name   

Connexin 26 (CX26), ELISA Kit

 Also Known As   

Camel Connexin 26 ELISA Kit

 Product Gene Name   

CX26 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 13; NC_000013.10 (20761602..20767114, complement). Location: 13q11-q12
 OMIM    121011
 3D Structure    ModBase 3D Structure for P29033
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 Species Reactivity    Camel
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CX26 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CX26 purchase    MBS108777 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Connexin 26 (CX26) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CX26. The ELISA analytical biochemical technique of the MBS108777 kit is based on CX26 antibody-CX26 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CX26 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CX26. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CX26. It may not necessarily be applicable to this product.
 NCBI GI #    19401867
 NCBI GeneID    2706
 NCBI Accession #    AAL87696.1 [Other Products]
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 UniProt Primary Accession #    P29033 [Other Products]
 UniProt Secondary Accession #    Q508A5; Q508A6; Q5YLL0; Q5YLL1; Q5YLL4; Q6IPV5; Q86U88; Q96AK0; Q9H536; Q9NNY4 [Other Products]
 UniProt Related Accession #    P29033 [Other Products]
 Molecular Weight    26,215 Da
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 NCBI Official Full Name    connexin 26
 NCBI Official Synonym Full Names    gap junction protein, beta 2, 26kDa
 NCBI Official Symbol    GJB2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    gap junction beta-2 protein; connexin 26; gap junction protein beta 2
 UniProt Protein Name    Gap junction beta-2 protein
 UniProt Synonym Protein Names   
 UniProt Gene Name    GJB2 [Similar Products]
 UniProt Synonym Gene Names    Cx26 [Similar Products]
 UniProt Entry Name    CXB2_HUMAN
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 NCBI Summary for CX26    This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
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 UniProt Comments for CX26    GJB2: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJB2 are the cause of deafness autosomal recessive type 1A (DFNB1A). DFNB1A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in GJB2 are the cause of deafness autosomal dominant type 3A (DFNA3A). Defects in GJB2 are a cause of Vohwinkel syndrome (VS). VS is an autosomal dominant disease characterized by hyperkeratosis, constriction on finger and toes and congenital deafness. Defects in GJB2 are a cause of palmoplantar keratoderma with deafness (PPKDFN). PPKDFN is an autosomal dominant disorder characterized by the association of palmoplantar hyperkeratosis with progressive, bilateral, high-frequency, sensorineural deafness. Defects in GJB2 are a cause of keratitis-ichthyosis- deafness syndrome (KID syndrome); an autosomal dominant form of ectodermal dysplasia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. KID syndrome is characterized by the association of hyperkeratotic skin lesions with vascularizing keratitis and profound sensorineural hearing loss. Clinical features include deafness, ichthyosis, photobia, absent or decreased eyebrows, sparse or absent scalp hair, decreased sweating and dysplastic finger and toenails. Defects in GJB2 are the cause of Bart-Pumphrey syndrome (BPS). BPS is an autosomal dominant disorder characterized by sensorineural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, It shows considerable phenotypic variability. Defects in GJB2 are the cause of ichthyosis hystrix-like with deafness syndrome (HID syndrome). HID syndrome is an autosomal-dominant inherited keratinizing disorder characterized by sensorineural deafness and spiky hyperkeratosis affecting the entire skin. HID syndrome is considered to differ from the similar KID syndrome in the extent and time of occurrence of skin symptoms and the severity of the associated keratitis. Belongs to the connexin family. Beta-type (group I) subfamily.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q11-q12

Cellular Component: connexon complex; integral to membrane; ER-Golgi intermediate compartment; plasma membrane; lateral plasma membrane

Molecular Function: gap junction channel activity

Biological Process: sensory perception of sound; cell-cell signaling; gap junction assembly; transport; male genitalia development; decidualization; response to progesterone stimulus; transmembrane transport; response to estradiol stimulus

Disease: Deafness, Autosomal Recessive 1a; Ichthyosis, Hystrix-like, With Deafness; Deafness, X-linked 2; Deafness, Congenital, With Keratopachydermia And Constrictions Of Fingers And Toes; Keratitis-ichthyosis-deafness Syndrome, Autosomal Dominant; Knuckle Pads, Leukonychia, And Sensorineural Deafness; Keratoderma, Palmoplantar, With Deafness; Deafness, Autosomal Dominant 3a
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 Research Articles on CX26    1. GJB2 mutated alleles were observed in 40% (31/77) of Amazonian deaf patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CX26 elisa kitDiseases associated with CX26 elisa kit
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Gap Junction Assembly Pathway antibodies  Gap Junction Assembly Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Oligomerization Of Connexins Into Connexons Pathway antibodies  Oligomerization Of Connexins Into Connexons Pathway Diagram
 Transport Of Connexins Along The Secretory Pathway antibodies  Transport Of Connexins Along The Secretory Pathway Diagram
 Transport Of Connexons To The Plasma Membrane Pathway antibodies  Transport Of Connexons To The Plasma Membrane Pathway Diagram
 Disease Name  Pubmed Publications
 Deafness Antibodies  >584 publications with CX26 and Deafness
 Hearing Loss, Sensorineural Antibodies  >368 publications with CX26 and Hearing Loss, Sensorineural
 Keratitis Antibodies  >49 publications with CX26 and Keratitis
 Ichthyosis Antibodies  >48 publications with CX26 and Ichthyosis
 Keratoderma, Palmoplantar Antibodies  >41 publications with CX26 and Keratoderma, Palmoplantar
 Keratoderma palmoplantar deafness Antibodies  >25 publications with CX26 and Keratoderma palmoplantar deafness
 Vohwinkel syndrome Antibodies  >14 publications with CX26 and Vohwinkel syndrome
 Neoplasms Antibodies  >10 publications with CX26 and Neoplasms
 Psoriasis Antibodies  >7 publications with CX26 and Psoriasis
Organs/Tissues associated with CX26 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Ear Antibodies  >137 publications with CX26 and Ear
 Skin Antibodies  >84 publications with CX26 and Skin
 Brain Antibodies  >30 publications with CX26 and Brain
 Eye Antibodies  >11 publications with CX26 and Eye
 Uterus Antibodies  >8 publications with CX26 and Uterus
 Larynx Antibodies  >4 publications with CX26 and Larynx
 Heart Antibodies  >3 publications with CX26 and Heart
 Mouth Antibodies  >3 publications with CX26 and Mouth
 Bladder Antibodies  >1 publications with CX26 and Bladder
 Intestine Antibodies  >1 publications with CX26 and Intestine
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