NP_963853.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,277 Da
NCBI Official Full Name
forkhead box protein O3
NCBI Official Synonym Full Names
forkhead box O3
NCBI Official Synonym Symbols
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2 [Similar Products]
NCBI Protein Information
forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
UniProt Protein Name
Forkhead box protein O3
UniProt Synonym Protein Names
AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
UniProt Synonym Gene Names
UniProt Entry Name
FOXO3_HUMAN
NCBI Summary for FOXO3
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXO3
FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
Protein type: Oncoprotein; Transcription factor; Autophagy; DNA-binding
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; protein kinase binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; initiation of primordial ovarian follicle growth; positive regulation of transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of erythrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; ovulation from ovarian follicle; glucose homeostasis; oocyte maturation; regulation of transcription from RNA polymerase II promoter; regulation of translation; positive regulation of neuron apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter
Research Articles on FOXO3
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Products associated with FOXO3 elisa kit
Pathways associated with FOXO3 elisa kit
Diseases associated with FOXO3 elisa kit
Organs/Tissues associated with FOXO3 elisa kit
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