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LMNA elisa kit :: Camel Lamin A/C ELISA Kit

Scan QR to view Datasheet Catalog #    MBS075488 LMNA elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lamin A/C (LMNA), ELISA Kit

 Also Known As   

Camel Lamin A/C ELISA Kit

 Product Gene Name   

LMNA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    115200
 3D Structure    ModBase 3D Structure for P02545
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 Species Reactivity    Camel
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LMNA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LMNA purchase    MBS075488 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lamin A/C (LMNA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LMNA. The ELISA analytical biochemical technique of the MBS075488 kit is based on LMNA antibody-LMNA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LMNA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LMNA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for LMNA. It may not necessarily be applicable to this product.
 NCBI GI #    27436946
 NCBI GeneID    4000
 NCBI Accession #    NP_733821.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_170707.3 [Other Products]
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 UniProt Primary Accession #    P02545 [Other Products]
 UniProt Secondary Accession #    P02546; Q5I6Y4; Q5I6Y6; Q5TCJ2; Q5TCJ3; Q6UYC3; Q969I8; B4DI32; D3DVB0; D6RAQ3; E7EUI9 [Other Products]
 UniProt Related Accession #    P02545 [Other Products]
 Molecular Weight    74,139 Da
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 NCBI Official Full Name    lamin isoform A
 NCBI Official Synonym Full Names    lamin A/C
 NCBI Official Symbol    LMNA [Similar Products]
 NCBI Official Synonym Symbols   
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
[Similar Products]
 NCBI Protein Information    lamin; 70 kDa lamin; prelamin-A/C; lamin A/C-like 1; renal carcinoma antigen NY-REN-32
 UniProt Protein Name    Prelamin-A/C
 UniProt Synonym Protein Names   
70 kDa lamin; Renal carcinoma antigen NY-REN-32
 Protein Family    Lamin
 UniProt Gene Name    LMNA [Similar Products]
 UniProt Synonym Gene Names    LMN1 [Similar Products]
 UniProt Entry Name    LMNA_HUMAN
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 NCBI Summary for LMNA    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
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 UniProt Comments for LMNA    lamin A/C: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: nucleoplasm; nuclear lamina; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; lamin filament; intermediate filament; nuclear speck; nuclear envelope; nucleus; cytosol

Molecular Function: protein binding; structural molecule activity

Biological Process: mitotic nuclear envelope reassembly; muscle development; apoptosis; unfolded protein response; ventricular cardiac muscle cell development; mitotic nuclear envelope disassembly; regulation of cell migration; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; sterol regulatory element binding protein nuclear translocation; mitotic cell cycle; establishment and/or maintenance of microtubule cytoskeleton polarity; cell structure disassembly during apoptosis

Disease: Heart-hand Syndrome, Slovenian Type; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Restrictive Dermopathy, Lethal; Muscular Dystrophy, Congenital, Lmna-related; Mandibuloacral Dysplasia With Type A Lipodystrophy; Charcot-marie-tooth Disease, Axonal, Type 2b1; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Lipodystrophy, Familial Partial, Type 2; Hutchinson-gilford Progeria Syndrome; Cardiomyopathy, Dilated, 1a; Muscular Dystrophy, Limb-girdle, Type 1b; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism
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 Research Articles on LMNA    1. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LMNA elisa kitPathways associated with LMNA elisa kit
 Reference Product  PubMed Publications
 EMD elisa kit  >17 publications with LMNA and EMD
 LMNB1 elisa kit  >14 publications with LMNA and LMNB1
 LMNB2 elisa kit  >10 publications with LMNA and LMNB2
 SYNE1 elisa kit  >5 publications with LMNA and SYNE1
 CASP6 elisa kit  >3 publications with LMNA and CASP6
 TMPO elisa kit  >2 publications with LMNA and TMPO
 FOS elisa kit  >2 publications with LMNA and FOS
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with LMNA elisa kitOrgans/Tissues associated with LMNA elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >263 publications with LMNA and Cardiovascular Diseases
 Progeria Antibodies  >245 publications with LMNA and Progeria
 Heart Diseases Antibodies  >230 publications with LMNA and Heart Diseases
 Cardiomyopathy, Dilated Antibodies  >190 publications with LMNA and Cardiomyopathy, Dilated
 Muscular Dystrophy, Emery-Dreifuss Antibodies  >135 publications with LMNA and Muscular Dystrophy, Emery-Dreifuss
 Lipodystrophy, Familial Partial Antibodies  >129 publications with LMNA and Lipodystrophy, Familial Partial
 Death, Sudden, Cardiac Antibodies  >47 publications with LMNA and Death, Sudden, Cardiac
 Muscular Dystrophies, Limb-Girdle Antibodies  >38 publications with LMNA and Muscular Dystrophies, Limb-Girdle
 Heart Block Antibodies  >32 publications with LMNA and Heart Block
 Werner Syndrome Antibodies  >27 publications with LMNA and Werner Syndrome
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >261 publications with LMNA and Muscle
 Heart Antibodies  >170 publications with LMNA and Heart
 Skin Antibodies  >114 publications with LMNA and Skin
 Adipose Tissue Antibodies  >87 publications with LMNA and Adipose Tissue
 Blood Antibodies  >78 publications with LMNA and Blood
 Bone Antibodies  >70 publications with LMNA and Bone
 Nerve Antibodies  >50 publications with LMNA and Nerve
 Connective Tissue Antibodies  >44 publications with LMNA and Connective Tissue
 Vascular Antibodies  >40 publications with LMNA and Vascular
 Brain Antibodies  >23 publications with LMNA and Brain
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