AAH72015.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
504,606 Da
NCBI Official Full Name
LRP1 protein
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein 1
NCBI Official Synonym Symbols
APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R [Similar Products]
NCBI Protein Information
prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor
UniProt Protein Name
Prolow-density lipoprotein receptor-related protein 1
UniProt Synonym Protein Names
Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor
UniProt Synonym Gene Names
UniProt Entry Name
LRP1_HUMAN
NCBI Summary for LRP1
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
UniProt Comments for LRP1
LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: focal adhesion; cell soma; clathrin-coated vesicle; integral to plasma membrane; lysosomal membrane; cytoplasm; dendrite; nucleolus; plasma membrane; coated pit; endosome; receptor complex
Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; receptor activity; calcium ion binding
Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; phototransduction, visible light; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; positive regulation of lipid transport; cell proliferation; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; regulation of cholesterol transport; retinoid metabolic process; apoptotic cell clearance; aging
Research Articles on LRP1
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Pathways associated with LRP1 elisa kit
Diseases associated with LRP1 elisa kit
Organs/Tissues associated with LRP1 elisa kit
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