AAF37697.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,656 Da
NCBI Official Full Name
mannose phosphate isomerase
NCBI Official Synonym Full Names
mannose phosphate isomerase
NCBI Protein Information
mannose-6-phosphate isomerase; phosphohexomutase; phosphomannose isomerase 1; mannose-6- phosphate isomerase
UniProt Protein Name
Mannose-6-phosphate isomerase
UniProt Synonym Protein Names
Phosphohexomutase; Phosphomannose isomerase
UniProt Synonym Gene Names
UniProt Entry Name
MPI_HUMAN
NCBI Summary for MPI
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. [provided by RefSeq, Jul 2008]
UniProt Comments for MPI
MPI: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B); also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under- glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy. Belongs to the mannose-6-phosphate isomerase type 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC 5.3.1.8; Isomerase; Carbohydrate Metabolism - amino sugar and nucleotide sugar
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: cytosol
Molecular Function: mannose-6-phosphate isomerase activity; zinc ion binding
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; GDP-mannose biosynthetic process; post-translational protein modification
Disease: Congenital Disorder Of Glycosylation, Type Ib
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Products associated with MPI elisa kit
Pathways associated with MPI elisa kit
Diseases associated with MPI elisa kit
Organs/Tissues associated with MPI elisa kit
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