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NEPHRIN elisa kit :: Camel Nephrin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS096540 NEPHRIN elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nephrin, ELISA Kit

 Also Known As   

Camel Nephrin ELISA Kit

 Product Gene Name   

NEPHRIN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Chromosome Location    Chromosome: 19; NC_000019.9 (36316274..36342895, complement). Location: 19q13.1
 OMIM    256300
 3D Structure    ModBase 3D Structure for O60500
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 Species Reactivity    Camel
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of NEPHRIN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NEPHRIN purchase    MBS096540 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Nephrin, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NEPHRIN. The ELISA analytical biochemical technique of the MBS096540 kit is based on NEPHRIN antibody-NEPHRIN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NEPHRIN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NEPHRIN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for NEPHRIN. It may not necessarily be applicable to this product.
 NCBI GI #    10441644
 NCBI GeneID    4868
 NCBI Accession #    AAG17141.1 [Other Products]
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 UniProt Primary Accession #    O60500 [Other Products]
 UniProt Secondary Accession #    A6NDH2; C3RX61 [Other Products]
 UniProt Related Accession #    O60500 [Other Products]
 Molecular Weight    134,742 Da
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 NCBI Official Full Name    nephrin
 NCBI Official Synonym Full Names    nephrosis 1, congenital, Finnish type (nephrin)
 NCBI Official Symbol    NPHS1 [Similar Products]
 NCBI Official Synonym Symbols   
CNF; NPHN; nephrin
[Similar Products]
 NCBI Protein Information    nephrin; renal glomerulus-specific cell adhesion receptor
 UniProt Protein Name    Nephrin
 UniProt Synonym Protein Names   
Renal glomerulus-specific cell adhesion receptor
 Protein Family    Nephrin
 UniProt Gene Name    NPHS1 [Similar Products]
 UniProt Synonym Gene Names    NPHN [Similar Products]
 UniProt Entry Name    NPHN_HUMAN
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 NCBI Summary for NEPHRIN    This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]
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 UniProt Comments for NEPHRIN    NPHS1: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Interacts with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1. Interacts with NPHS2. Specifically expressed in podocytes of kidney glomeruli. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell projection; protein complex; integral to plasma membrane; plasma membrane; lipid raft

Molecular Function: protein domain specific binding; protein binding; spectrin binding; myosin binding; alpha-actinin binding

Biological Process: skeletal muscle development; positive regulation of actin filament polymerization; glomerular basement membrane development; JNK cascade; cell adhesion; excretion; myoblast fusion

Disease: Nephrotic Syndrome, Type 1
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 Research Articles on NEPHRIN    1. Nck may facilitate dynamic signaling events at the slit diaphragm by promoting Fyn-dependent phosphorylation of nephrin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NEPHRIN elisa kitPathways associated with NEPHRIN elisa kit
 Reference Product  PubMed Publications
 NPHS2 elisa kit  >66 publications with NEPHRIN and NPHS2
 CD2AP elisa kit  >22 publications with NEPHRIN and CD2AP
 TJP1 elisa kit  >6 publications with NEPHRIN and TJP1
 TRPC6 elisa kit  >6 publications with NEPHRIN and TRPC6
 SRC elisa kit  >4 publications with NEPHRIN and SRC
 KIRREL elisa kit  >4 publications with NEPHRIN and KIRREL
 FYN elisa kit  >1 publications with NEPHRIN and FYN
 Products by Pathway  Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Nephrin Interactions Pathway antibodies  Nephrin Interactions Pathway Diagram
 Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway antibodies  Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway Diagram
Diseases associated with NEPHRIN elisa kitOrgans/Tissues associated with NEPHRIN elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >124 publications with NEPHRIN and Kidney Diseases
 Nephrosis Antibodies  >97 publications with NEPHRIN and Nephrosis
 Proteinuria Antibodies  >71 publications with NEPHRIN and Proteinuria
 Glomerulonephritis Antibodies  >33 publications with NEPHRIN and Glomerulonephritis
 Glomerulosclerosis, Focal Segmental Antibodies  >30 publications with NEPHRIN and Glomerulosclerosis, Focal Segmental
 Renal Insufficiency Antibodies  >14 publications with NEPHRIN and Renal Insufficiency
 Kidney Failure, Chronic Antibodies  >13 publications with NEPHRIN and Kidney Failure, Chronic
 Hypertension Antibodies  >8 publications with NEPHRIN and Hypertension
 Albuminuria Antibodies  >6 publications with NEPHRIN and Albuminuria
 Fibrosis Antibodies  >5 publications with NEPHRIN and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >118 publications with NEPHRIN and Kidney
 Pancreas Antibodies  >8 publications with NEPHRIN and Pancreas
 Brain Antibodies  >6 publications with NEPHRIN and Brain
 Thymus Antibodies  >3 publications with NEPHRIN and Thymus
 Testis Antibodies  >2 publications with NEPHRIN and Testis
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