ADB12634.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,538 Da
NCBI Official Full Name
neuroligin 3
NCBI Official Synonym Full Names
neuroligin 3
NCBI Official Synonym Symbols
NCBI Protein Information
neuroligin-3
UniProt Protein Name
Neuroligin-3
UniProt Synonym Protein Names
Gliotactin homolog
UniProt Synonym Gene Names
UniProt Entry Name
NLGN3_HUMAN
NCBI Summary for NLGN3
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for NLGN3
NLGN3: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1). AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1). ASPGX1 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cell junction; cell soma; cell surface; dendrite; endocytic vesicle; excitatory synapse; extracellular space; integral to plasma membrane; synapse
Molecular Function: cell adhesion molecule binding; neurexin binding; protein binding; receptor activity
Biological Process: adult behavior; axon extension; learning; neurological control of breathing; neuron adhesion; oligodendrocyte differentiation; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; receptor-mediated endocytosis; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of synaptic transmission; rhythmic synaptic transmission; social behavior; synapse organization and biogenesis; synaptic vesicle endocytosis; synaptogenesis; visual learning
Disease: Asperger Syndrome, X-linked, Susceptibility To, 1; Autism, Susceptibility To, X-linked 1
Research Articles on NLGN3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with NLGN3 elisa kit
Pathways associated with NLGN3 elisa kit
Diseases associated with NLGN3 elisa kit
Organs/Tissues associated with NLGN3 elisa kit
|