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P53 elisa kit :: Camel P53 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS059409 P53 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P53, ELISA Kit

★Popular Item★
 Also Known As   

Camel P53 ELISA Kit

 Product Gene Name   

P53 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 17; NC_000017.10 (7571720..7590868, complement). Location: 17p13.1
 OMIM    133239
 3D Structure    ModBase 3D Structure for P04637
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 Species Reactivity    Camel
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Assay Type    Quantitative Sandwich
 Detection Range    62.5 pg/ml - 2000 pg/ml
 Sensitivity    10 pg/ml
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of P53 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for P53 purchase    MBS059409 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the P53, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5 pg/ml - 2000 pg/ml in biological research samples containing P53, with an estimated sensitivity of 10 pg/ml. The ELISA analytical biochemical technique of the MBS059409 kit is based on P53 antibody-P53 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect P53 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, P53. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for P53 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of P53 (hereafter termed "analyte") in undiluted original Camel body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS059409. Click to request current manual
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NCBI/Uniprot data below describe general gene information for P53. It may not necessarily be applicable to this product.
 NCBI GI #    23491729
 NCBI GeneID    7157
 NCBI Accession #    BAC16799.1 [Other Products]
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 UniProt Primary Accession #    P04637 [Other Products]
 UniProt Secondary Accession #    Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98 [Other Products]
 UniProt Related Accession #    P04637 [Other Products]
 Molecular Weight    43,653 Da
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 NCBI Official Full Name    P53
 NCBI Official Synonym Full Names    tumor protein p53
 NCBI Official Symbol    TP53 [Similar Products]
 NCBI Official Synonym Symbols   
P53; BCC7; LFS1; TRP53
[Similar Products]
 NCBI Protein Information    cellular tumor antigen p53; antigen NY-CO-13; phosphoprotein p53; p53 tumor suppressor; transformation-related protein 53
 UniProt Protein Name    Cellular tumor antigen p53
 UniProt Synonym Protein Names   
Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
 Protein Family    p53 and DNA damage-regulated protein
 UniProt Gene Name    TP53 [Similar Products]
 UniProt Synonym Gene Names    P53 [Similar Products]
 UniProt Entry Name    P53_HUMAN
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 NCBI Summary for P53    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
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 UniProt Comments for P53    p53: a transcription factor and major tumor suppressor that plays a major role in regulating cellular responses to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. More than 50 percent of human tumors contain a mutation or deletion of the TP53 gene. p53 is modified post-translationally at multiple sites. DNA damage induces phosphorylation of p53 at S15, S20 and S37, reducing its interaction with the oncoprotein MDM2. MDM2 inhibits p53 accumulation by targeting it for ubiquitination and proteasomal degradation. Phosphorylated by many kinases including Chk2 and Chk1 at S20, enhancing its tetramerization, stability and activity. The phosphorylation by CAK at S392 is increased in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. Phosphorylation of p53 at S46 regulates the ability of p53 to induce apoptosis. The acetylation of p53 appears to play a positive role in the accumulation of p53 during the stress response. Following DNA damage, p53 becomes acetylated at K382, enhancing its binding to DNA. Deacetylation of p53 can occur through interaction with SIRT1, a deacetylase that may be involved in cellular aging and the DNA damage response. p53 regulates the transcription of a set of genes encoding endosomal proteins that regulate endosomal functions. These include STEAP3 and CHMP4C, which enhance exosome production, and CAV1 and CHMP4C, which produce a more rapid endosomal clearance of the EGFR from the plasma membrane. DNA damage regulates a p53-mediated secretory pathway, increasing the secretion of some proteins such as Hsp90, SERPINE1, SERPINB5, NKEF-A, and CyPA, and inhibiting the secretion of others including CTSL and IGFBP-2. Two alternatively spliced human isoforms have been reported. Isoform 2 is expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Protein type: Tumor suppressor; DNA-binding; Transcription factor; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Activator

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: PML body; transcription factor TFIID complex; nuclear matrix; protein complex; mitochondrion; endoplasmic reticulum; replication fork; cytosol; nucleoplasm; nuclear body; mitochondrial matrix; nuclear chromatin; cytoplasm; nucleolus; chromatin; nucleus

Molecular Function: identical protein binding; protease binding; zinc ion binding; protein phosphatase 2A binding; p53 binding; protein N-terminus binding; receptor tyrosine kinase binding; transcription factor binding; protein kinase binding; protein phosphatase binding; histone acetyltransferase binding; protein binding; copper ion binding; enzyme binding; histone deacetylase regulator activity; DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; chaperone binding; damaged DNA binding; chromatin binding; transcription factor activity; ATP binding

Biological Process: viral reproduction; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; multicellular organismal development; T cell differentiation in the thymus; gastrulation; determination of adult life span; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to antibiotic; regulation of apoptosis; cellular response to glucose starvation; protein localization; negative regulation of neuroblast proliferation; base-excision repair; transforming growth factor beta receptor signaling pathway; cerebellum development; protein complex assembly; cell cycle arrest; ER overload response; response to X-ray; release of cytochrome c from mitochondria; somitogenesis; chromatin assembly; cell aging; circadian behavior; rRNA transcription; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of DNA replication; negative regulation of fibroblast proliferation; embryonic organ development; positive regulation of transcription from RNA polymerase II promoter; regulation of mitochondrial membrane permeability; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; regulation of tissue remodeling; transcription from RNA polymerase II promoter; G1 DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator; apoptosis; negative regulation of transcription from RNA polymerase II promoter; response to salt stress; entrainment of circadian clock by photoperiod; negative regulation of cell proliferation; positive regulation of protein oligomerization; positive regulation of histone deacetylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-dependent; T cell proliferation during immune response; double-strand break repair; positive regulation of neuron apoptosis; response to gamma radiation; cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein tetramerization; mitochondrial DNA repair; Notch signaling pathway; in utero embryonic development; B cell lineage commitment; multicellular organism growth; cell proliferation; T cell lineage commitment; neuron apoptosis; negative regulation of helicase activity; nucleotide-excision repair; protein import into nucleus, translocation; Ras protein signal transduction; DNA strand renaturation; negative regulation of cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; blood coagulation; response to DNA damage stimulus

Disease: Papilloma Of Choroid Plexus; Pancreatic Cancer; Nasopharyngeal Carcinoma; Li-fraumeni Syndrome 1; Breast Cancer; Osteogenic Sarcoma; Colorectal Cancer; Adrenocortical Carcinoma, Hereditary; Glioma Susceptibility 1; Hepatocellular Carcinoma; Basal Cell Carcinoma, Susceptibility To, 7
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 Research Articles on P53    1. study elucidates a novel correlation between the tumor suppressor gene p53 and the oncogene Ras in regulating EMT program, and expands the knowledge about the function of p53 in EMT process
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with P53 elisa kitDiseases associated with P53 elisa kit
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of NOXA And Translocation To Mitochondria Pathway antibodies  Activation Of NOXA And Translocation To Mitochondria Pathway Diagram
 Activation Of PUMA And Translocation To Mitochondria Pathway antibodies  Activation Of PUMA And Translocation To Mitochondria Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2213 publications with P53 and Carcinoma
 Urogenital Neoplasms Antibodies  >960 publications with P53 and Urogenital Neoplasms
 Breast Neoplasms Antibodies  >869 publications with P53 and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >601 publications with P53 and Colorectal Neoplasms
 Carcinoma, Squamous Cell Antibodies  >530 publications with P53 and Carcinoma, Squamous Cell
 Glioma Antibodies  >467 publications with P53 and Glioma
 Cell Transformation, Neoplastic Antibodies  >327 publications with P53 and Cell Transformation, Neoplastic
 Carcinoma, Small Cell Antibodies  >319 publications with P53 and Carcinoma, Small Cell
 Neoplasm Metastasis Antibodies  >289 publications with P53 and Neoplasm Metastasis
 Sarcoma Antibodies  >278 publications with P53 and Sarcoma
Organs/Tissues associated with P53 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >715 publications with P53 and Blood
 Lung Antibodies  >581 publications with P53 and Lung
 Brain Antibodies  >489 publications with P53 and Brain
 Liver Antibodies  >298 publications with P53 and Liver
 Skin Antibodies  >260 publications with P53 and Skin
 Lymph Antibodies  >234 publications with P53 and Lymph
 Prostate Antibodies  >181 publications with P53 and Prostate
 Vascular Antibodies  >160 publications with P53 and Vascular
 Muscle Antibodies  >119 publications with P53 and Muscle
 Kidney Antibodies  >110 publications with P53 and Kidney
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