NP_001317280.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,866 Da
NCBI Official Full Name
tropomyosin alpha-1 chain isoform 12
NCBI Official Synonym Full Names
tropomyosin 1 (alpha)
NCBI Official Synonym Symbols
CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha [Similar Products]
NCBI Protein Information
tropomyosin alpha-1 chain
UniProt Protein Name
Tropomyosin alpha-1 chain
UniProt Synonym Protein Names
Alpha-tropomyosin; Tropomyosin-1
UniProt Synonym Gene Names
NCBI Summary for TPM1
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for TPM1
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Research Articles on TPM1
Precautions
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Disclaimer
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Pathways associated with TPM1 elisa kit
Diseases associated with TPM1 elisa kit
Disease Name |
Pubmed Publications |
Heart Diseases Antibodies |
>95 publications with TPM1 and Heart Diseases |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>32 publications with TPM1 and Cardiomyopathy, Hypertrophic, Familial |
Hypertrophy Antibodies |
>30 publications with TPM1 and Hypertrophy |
Breast Neoplasms Antibodies |
>19 publications with TPM1 and Breast Neoplasms |
Disease Models, Animal Antibodies |
>13 publications with TPM1 and Disease Models, Animal |
Cell Transformation, Neoplastic Antibodies |
>12 publications with TPM1 and Cell Transformation, Neoplastic |
Cardiomyopathy, Familial Hypertrophic, 3 Antibodies |
>11 publications with TPM1 and Cardiomyopathy, Familial Hypertrophic, 3 |
Fibrosis Antibodies |
>11 publications with TPM1 and Fibrosis |
Inflammation Antibodies |
>6 publications with TPM1 and Inflammation |
Kidney Diseases Antibodies |
>6 publications with TPM1 and Kidney Diseases |
Organs/Tissues associated with TPM1 elisa kit
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