KYN40481.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
255,047 Da
NCBI Official Full Name
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1, partial
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1
UniProt Synonym Gene Names
UniProt Entry Name
PLCE1_MOUSE
UniProt Comments for PLCE1
PLCE1: a widely expressed bifunctional enzyme with phospholipase activity and Ras guanine-exchange factor (RasGEF) activity. Catalyzes the release of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) from 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. Is an effector of heterotrimeric G protein activation. May play a role in cell survival, cell growth, actin organization and T-cell activation. Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs. Interacts with RHOA. Interacts with IQGAP1, HRAS, RAP1A, RAP2A, RAP2B and RRAS. Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Requires calcium for activiation. The Ras-associating domain 1 is degenerate and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane. The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway. Defects in PLCE1 are the cause of nephrotic syndrome type 3 (NPHS3). Nephrotic syndrome, a malfunction of the kidney glomerular filter, leads to proteinuria, hypoalbuminemia, edema. Overexpressed during heart failure. A GWAS study identified an association between esophageal squamous cell carcinoma and a common DNA variant in the PLCE1 gene in East Asians. Two isoforms of the human protein are produced by alternative splicing. Isoform 1 is broadly expressed and only absent in peripheral blood leukocytes. Isoform 2 is specifically expressed in placenta, lung and spleen. Isoform 1 and isoform 2 associate with Golgi membranes.
Protein type: Phospholipase; GAPs, Ras; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; GAPs
Cellular Component: cytoplasm; cytosol; Golgi apparatus; membrane; plasma membrane
Molecular Function: enzyme binding; guanyl-nucleotide exchange factor activity; hydrolase activity; phosphoinositide phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity; protein binding; Ras GTPase binding; signal transducer activity
Biological Process: activation of MAPK activity; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); glomerulus development; lipid catabolic process; lipid metabolic process; Ras protein signal transduction; regulation of G-protein coupled receptor protein signaling pathway; regulation of protein kinase activity; regulation of Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction
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Diseases associated with PLCE1 elisa kit
Organs/Tissues associated with PLCE1 elisa kit
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