NP_006817.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
14-3-3 protein theta
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
NCBI Protein Information
14-3-3 protein theta; 14-3-3 protein tau; 14-3-3 protein T-cell; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
UniProt Protein Name
14-3-3 protein theta
UniProt Synonym Protein Names
14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1
UniProt Entry Name
1433T_HUMAN
NCBI Summary for YWHAQ
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
UniProt Comments for YWHAQ
14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: focal adhesion; cytoplasmic vesicle membrane; membrane; cytoplasm; cytosol
Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding
Biological Process: substantia nigra development; apoptosis; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting
Research Articles on YWHAQ
1. Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT, APAF1, BCL2, BAD, BID, MCL1, BIRC4, BCL2L1, ENDOG, YWHAB, and YWHAQ, influence promoter activity in an allele-specific manner.
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Products associated with YWHAQ elisa kit
Pathways associated with YWHAQ elisa kit
Diseases associated with YWHAQ elisa kit
Organs/Tissues associated with YWHAQ elisa kit
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