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ADAMTS4 elisa kit :: Canine A Disintegrin Like and Metalloproteinase With Thrombospondin Type 1 Motif 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS028730 ADAMTS4 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin Like and Metalloproteinase With Thrombospondin Type 1 Motif 4 (ADAMTS4), ELISA Kit

★Popular Item★
 Also Known As   

Canine A Disintegrin Like and Metalloproteinase With Thrombospondin Type 1 Motif 4 ELISA Kit

 Product Gene Name   

ADAMTS4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (161159538..161168845, complement). Location: 1q21-q23
 OMIM    603876
 3D Structure    ModBase 3D Structure for O75173
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 Species Reactivity    Canine
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 Specificity    No significant cross-reactivity or interference between Canine ADAMTS4 and analogues was observed.
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 Samples    Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids
 Assay Type    Sandwich
 Detection Range    6.25 ng/ml - 200 ng/ml.
 Sensitivity    1.0 ng/ml.
 Intended Uses    This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated ADAMTS4 concentrations in Canine serum, plasma and other body fluids. Using Purified Canine ADAMTS4 antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add ADAMTS4 and ADAMTS4 antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of ADAMTS4 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ADAMTS4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ADAMTS4 purchase    MBS028730 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin Like and Metalloproteinase With Thrombospondin Type 1 Motif 4 (ADAMTS4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 6.25 ng/ml - 200 ng/ml in biological research samples containing ADAMTS4, with an estimated sensitivity of 1.0 ng/ml. The ELISA analytical biochemical technique of the MBS028730 kit is based on ADAMTS4 antibody-ADAMTS4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTS4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTS4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ADAMTS4 elisa kit

   Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated ADAMTS4 concentrations in Canine serum, plasma and other body fluids. Using Purified Canine ADAMTS4 antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add ADAMTS4 and ADAMTS4 antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of ADAMTS4 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
Sample Manual Insert of MBS028730. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ADAMTS4. It may not necessarily be applicable to this product.
 NCBI GI #    157427675
 NCBI GeneID    9507
 NCBI Accession #    NP_005090.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005099.4 [Other Products]
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 UniProt Primary Accession #    O75173 [Other Products]
 UniProt Secondary Accession #    Q5VTW2; Q6P4Q8; Q6UWA8; Q9UN83 [Other Products]
 UniProt Related Accession #    O75173 [Other Products]
 Molecular Weight    90,197 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 4
 NCBI Official Symbol    ADAMTS4 [Similar Products]
 NCBI Official Synonym Symbols   
ADMP-1; ADAMTS-2; ADAMTS-4
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 4
 UniProt Synonym Protein Names   
ADMP-1; Aggrecanase-1
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS4 [Similar Products]
 UniProt Synonym Gene Names    KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4 [Similar Products]
 UniProt Entry Name    ATS4_HUMAN
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 NCBI Summary for ADAMTS4    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTS4    ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: Protease; Secreted, signal peptide; EC 3.4.24.82; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; protein binding; protease binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development
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 Research Articles on ADAMTS4    1. AMTS4 has roles in melanoma growth and angiogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAMTS4 elisa kitPathways associated with ADAMTS4 elisa kit
 Reference Product  PubMed Publications
 ACAN elisa kit  >6 publications with ADAMTS4 and ACAN
 BCAN elisa kit  >3 publications with ADAMTS4 and BCAN
 TGFB1 elisa kit  >3 publications with ADAMTS4 and TGFB1
 FURIN elisa kit  >3 publications with ADAMTS4 and FURIN
 OSM elisa kit  >2 publications with ADAMTS4 and OSM
 IL1B elisa kit  >2 publications with ADAMTS4 and IL1B
 IL17A elisa kit  >1 publications with ADAMTS4 and IL17A
 SRPX2 elisa kit  >1 publications with ADAMTS4 and SRPX2
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with ADAMTS4 elisa kitOrgans/Tissues associated with ADAMTS4 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with ADAMTS4 and Inflammation
 Neoplasms Antibodies  >14 publications with ADAMTS4 and Neoplasms
 Necrosis Antibodies  >14 publications with ADAMTS4 and Necrosis
 Arthritis, Rheumatoid Antibodies  >7 publications with ADAMTS4 and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >5 publications with ADAMTS4 and Nervous System Diseases
 Atherosclerosis Antibodies  >5 publications with ADAMTS4 and Atherosclerosis
 Brain Diseases Antibodies  >5 publications with ADAMTS4 and Brain Diseases
 Heart Diseases Antibodies  >4 publications with ADAMTS4 and Heart Diseases
 Myocardial Infarction Antibodies  >4 publications with ADAMTS4 and Myocardial Infarction
 Carcinoma, Squamous Cell Antibodies  >2 publications with ADAMTS4 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with ADAMTS4 and Brain
 Muscle Antibodies  >4 publications with ADAMTS4 and Muscle
 Embryonic Tissue Antibodies  >3 publications with ADAMTS4 and Embryonic Tissue
 Lung Antibodies  >1 publications with ADAMTS4 and Lung
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