NP_055058.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
135,603 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 3
NCBI Official Synonym Symbols
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 3; ADAM-TS3; ADAMTS-3; PC II-NP; ADAM-TS 3; zinc metalloendopeptidase; procollagen II N-proteinase; procollagen II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 3
UniProt Synonym Protein Names
Procollagen II N-proteinase; PC II-NP; Procollagen II amino propeptide-processing enzyme
UniProt Synonym Gene Names
UniProt Entry Name
ATS3_HUMAN
NCBI Summary for ADAMTS3
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS3
ADAMTS3: Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
Protein type: Secreted; Protease; EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region
Molecular Function: heparin binding; protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity
Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; fibril organization and biogenesis; protein processing; proteolysis; collagen biosynthetic process
Research Articles on ADAMTS3
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Pathways associated with ADAMTS3 elisa kit
Diseases associated with ADAMTS3 elisa kit
Organs/Tissues associated with ADAMTS3 elisa kit
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