AAA37169.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,707 Da
NCBI Official Full Name
adrenocorticotropic hormone, partial
NCBI Official Synonym Full Names
pro-opiomelanocortin-alpha
NCBI Official Synonym Symbols
BE; Npp; ACTH; Clip; Pomc1; Pomc-1; Beta-LPH; alphaMSH; beta-MSH; Gamma-LPH; alpha-MSH; gamma-MSH [Similar Products]
NCBI Protein Information
pro-opiomelanocortin
UniProt Protein Name
Pro-opiomelanocortin
UniProt Synonym Protein Names
Corticotropin-lipotropin
UniProt Synonym Gene Names
UniProt Entry Name
COLI_MOUSE
NCBI Summary for ACTH
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for ACTH
POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; peroxisomal matrix; cytoplasm; extracellular region; secretory granule
Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; hormone activity; type 4 melanocortin receptor binding; receptor binding
Biological Process: generation of precursor metabolites and energy; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; signal transduction; glucose homeostasis; cellular pigmentation
Research Articles on ACTH
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Pathways associated with ACTH elisa kit
Diseases associated with ACTH elisa kit
Organs/Tissues associated with ACTH elisa kit
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