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ALOX12B elisa kit :: Canine Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7210404 ALOX12B elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B), ELISA Kit

 Also Known As   

Canine Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) ELISA Kit

 Product Gene Name   

ALOX12B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    603741
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 Species Reactivity    Canine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact technical support.
 Other Notes    Small volumes of ALOX12B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ALOX12B purchase    MBS7210404 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ALOX12B. The ELISA analytical biochemical technique of the MBS7210404 kit is based on ALOX12B antibody-ALOX12B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ALOX12B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ALOX12B. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ALOX12B. It may not necessarily be applicable to this product.
 NCBI GI #    4502053
 NCBI GeneID    242
 NCBI Accession #    NP_001130.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001139.2 [Other Products]
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 UniProt Related Accession #    O75342 [Other Products]
 Molecular Weight    80,356 Da
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 NCBI Official Full Name    arachidonate 12-lipoxygenase, 12R-type
 NCBI Official Synonym Full Names    arachidonate 12-lipoxygenase, 12R type
 NCBI Official Symbol    ALOX12B [Similar Products]
 NCBI Official Synonym Symbols   
ARCI2; 12R-LOX
[Similar Products]
 NCBI Protein Information    arachidonate 12-lipoxygenase, 12R-type; 12R-lipoxygenase; epidermis-type lipoxygenase 12
 UniProt Protein Name    Arachidonate 12-lipoxygenase, 12R-type
 UniProt Synonym Protein Names   
Epidermis-type lipoxygenase 12
 Protein Family    Arachidonate 12-lipoxygenase
 UniProt Gene Name    ALOX12B [Similar Products]
 UniProt Synonym Gene Names    12R-LOX; 12R-lipoxygenase [Similar Products]
 UniProt Entry Name    LX12B_HUMAN
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 NCBI Summary for ALOX12B    This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ALOX12B    ALOX12B: Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE). Defects in ALOX12B are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non- bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the lipoxygenase family.

Protein type: EC 1.13.11.-; Oxidoreductase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytosol

Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; arachidonate 12-lipoxygenase activity; iron ion binding

Biological Process: sphingolipid metabolic process; lipoxygenase pathway; positive regulation of MAPKKK cascade; protein amino acid lipidation; ceramide biosynthetic process; arachidonic acid metabolic process; linoleic acid metabolic process; hepoxilin biosynthetic process

Disease: Ichthyosis, Congenital, Autosomal Recessive 2
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 Research Articles on ALOX12B    1. We found that the contribution of the ALOX12B gene to the pathogenesis of Autosomal Recessive Congenital Ichthyosis to be as important as that of TGM1 in families of Arab Muslim origin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ALOX12B elisa kitPathways associated with ALOX12B elisa kit
 Reference Product  PubMed Publications
 ALOX12 elisa kit  >8 publications with ALOX12B and ALOX12
 ALOX15B elisa kit  >7 publications with ALOX12B and ALOX15B
 ALOX15 elisa kit  >3 publications with ALOX12B and ALOX15
 PTGS2 elisa kit  >1 publications with ALOX12B and PTGS2
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Synthesis Of 12-eicosatetraenoic Acid Derivatives Pathway antibodies  Synthesis Of 12-eicosatetraenoic Acid Derivatives Pathway Diagram
Diseases associated with ALOX12B elisa kitOrgans/Tissues associated with ALOX12B elisa kit
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >23 publications with ALOX12B and Congenital Abnormalities
 Ichthyosis, Lamellar Antibodies  >12 publications with ALOX12B and Ichthyosis, Lamellar
 Inflammation Antibodies  >3 publications with ALOX12B and Inflammation
 Atherosclerosis Antibodies  >1 publications with ALOX12B and Atherosclerosis
 Lung Neoplasms Antibodies  >1 publications with ALOX12B and Lung Neoplasms
 Fatty Liver Antibodies  >1 publications with ALOX12B and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >22 publications with ALOX12B and Skin
 Lung Antibodies  >1 publications with ALOX12B and Lung
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