NP_000897.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
118,919 Da
NCBI Official Full Name
atrial natriuretic peptide receptor 1
NCBI Official Synonym Full Names
natriuretic peptide receptor 1
NCBI Official Synonym Symbols
ANPa; NPRA; ANPRA; GUC2A; GUCY2A [Similar Products]
NCBI Protein Information
atrial natriuretic peptide receptor 1; GC-A; ANP-A; NPR-A; ANPR-A; guanylate cyclase A; natriuretic peptide receptor A; atrionatriuretic peptide receptor A; natriuretic peptide A type receptor; atrial natriuretic peptide receptor type A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
UniProt Protein Name
Atrial natriuretic peptide receptor 1
UniProt Synonym Protein Names
Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A
UniProt Synonym Gene Names
UniProt Entry Name
ANPRA_HUMAN
NCBI Summary for NPR1
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
UniProt Comments for NPR1
ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction.
Protein type: Kinase, protein; EC 4.6.1.2; Protein kinase, dual-specificity (receptor); Lyase; Nucleotide Metabolism - purine; Guanylyl cyclase; Protein kinase, RGC; Membrane protein, integral; Receptor, misc.; RGC group; RGC family
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: integral to plasma membrane; receptor complex
Molecular Function: guanylate cyclase activity; hormone binding; GTP binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein kinase binding; ATP binding; protein kinase activity
Biological Process: cGMP biosynthetic process; negative regulation of smooth muscle cell proliferation; regulation of vasodilation; body fluid secretion; protein amino acid phosphorylation; dopamine metabolic process; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; positive regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; negative regulation of cell growth; regulation of vascular permeability; regulation of blood vessel size
Research Articles on NPR1
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Products associated with NPR1 elisa kit
Pathways associated with NPR1 elisa kit
Diseases associated with NPR1 elisa kit
Organs/Tissues associated with NPR1 elisa kit
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