NP_003986.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
111,208 Da
NCBI Official Full Name
atrial natriuretic peptide receptor 2
NCBI Official Synonym Full Names
natriuretic peptide receptor 2
NCBI Official Synonym Symbols
AMDM; ANPb; ECDM; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B [Similar Products]
NCBI Protein Information
atrial natriuretic peptide receptor 2; GC-B; ANP-B; NPR-B; ANPR-B; guanylate cyclase B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
UniProt Protein Name
Atrial natriuretic peptide receptor 2
UniProt Synonym Protein Names
Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B; GC-B
UniProt Synonym Gene Names
UniProt Entry Name
ANPRB_HUMAN
NCBI Summary for NPR2
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
UniProt Comments for NPR2
ANPB: natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. 21 mutations linked to acromesomelic dysplasia (skeletal malformation). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 4.6.1.2; Receptor, misc.; Membrane protein, integral; Guanylyl cyclase; Protein kinase, dual-specificity (receptor); Kinase, protein; Nucleotide Metabolism - purine; Lyase; Protein kinase, RGC; RGC group; RGC family
Chromosomal Location of Human Ortholog: 9p21-p12
Cellular Component: plasma membrane; integral to membrane
Molecular Function: identical protein binding; guanylate cyclase activity; transmembrane receptor activity; GTP binding; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; receptor activity; ATP binding; protein kinase activity
Biological Process: cGMP biosynthetic process; ossification; cell surface receptor linked signal transduction; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; negative regulation of meiotic cell cycle; signal transduction; protein amino acid phosphorylation
Disease: Short Stature With Nonspecific Skeletal Abnormalities; Epiphyseal Chondrodysplasia, Miura Type; Acromesomelic Dysplasia, Maroteaux Type
Research Articles on NPR2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with NPR2 elisa kit
Pathways associated with NPR2 elisa kit
Diseases associated with NPR2 elisa kit
Organs/Tissues associated with NPR2 elisa kit
|