NP_001124000.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
128,607 Da
NCBI Official Full Name
C-Jun-amino-terminal kinase-interacting protein 4 isoform 1
NCBI Official Synonym Full Names
sperm associated antigen 9
NCBI Official Synonym Symbols
JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4 [Similar Products]
NCBI Protein Information
C-Jun-amino-terminal kinase-interacting protein 4; sunday driver 1; Max-binding protein; sperm surface protein; lung cancer oncogene 4; JNK interacting protein; cancer/testis antigen 89; JNK/SAPK-associated protein; proliferation-inducing gene 6; protein highly expressed in testis; human lung cancer oncogene 6 protein; sperm associated antigen 9 variant 5; mitogen-activated protein kinase 8-interacting protein 4; c-Jun NH2-terminal kinase-associated leucine zipper protein
UniProt Protein Name
C-Jun-amino-terminal kinase-interacting protein 4
UniProt Synonym Protein Names
Cancer/testis antigen 89; CT89; Human lung cancer oncogene 6 protein; HLC-6; JNK-associated leucine-zipper protein; JLP; Mitogen-activated protein kinase 8-interacting protein 4; Proliferation-inducing protein 6; Protein highly expressed in testis; PHET; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1
UniProt Synonym Gene Names
HSS; KIAA0516; MAPK8IP4; SYD1; HLC6; JIP-4; JNK-interacting protein 4; CT89; HLC-6; JLP; PHET [Similar Products]
UniProt Entry Name
JIP4_HUMAN
NCBI Summary for SPAG9
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
UniProt Comments for SPAG9
JIP4: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. Isoform 3 is increased in systemic sclerosis fibroblasts. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. Belongs to the JIP scaffold family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: perinuclear region of cytoplasm; cytoplasm; integral to membrane; acrosome; cytosol
Molecular Function: JUN kinase binding; MAP-kinase scaffold activity; protein binding; receptor signaling complex scaffold activity; mitogen-activated protein kinase p38 binding; kinesin binding
Biological Process: muscle cell differentiation; positive regulation of muscle cell differentiation; striated muscle cell differentiation; spermatogenesis; positive regulation of neuron differentiation; retrograde transport, endosome to Golgi; activation of JNK activity; protein homooligomerization; positive regulation of cell migration
Research Articles on SPAG9
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Pathways associated with SPAG9 elisa kit
Diseases associated with SPAG9 elisa kit
Organs/Tissues associated with SPAG9 elisa kit
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