NP_775157.2
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
24,023 Da
NCBI Official Full Name
CDK5 regulatory subunit-associated protein 2
NCBI Official Synonym Full Names
CDK5 regulatory subunit associated protein 2
NCBI Protein Information
CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48
UniProt Protein Name
CDK5 regulatory subunit-associated protein 2
UniProt Synonym Protein Names
CDK5 activator-binding protein C48
UniProt Entry Name
CK5P2_RAT
NCBI Summary for CDK5RAP2
neuronal cyclin-dependent kinase 5 (Cdk5) activator binding protein [RGD, Feb 2006]
UniProt Comments for CDK5RAP2
CDK5RAP2: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Defects in CDK5RAP2 are the cause of microcephaly primary type 3 (MCPH3). A disorder defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Cellular Component: Golgi apparatus; spindle pole; microtubule; centrosome; pericentriolar material; cell; perinuclear region of cytoplasm; cytoplasm; cell junction
Molecular Function: calmodulin binding; tubulin binding; microtubule binding; protein complex binding; protein kinase binding
Biological Process: negative regulation of neuron differentiation; neurogenesis; establishment of mitotic spindle orientation; regulation of neuron differentiation; centrosome organization and biogenesis; positive regulation of transcription, DNA-dependent; microtubule cytoskeleton organization and biogenesis; brain development; negative regulation of centriole replication; microtubule bundle formation; chromosome segregation
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Products associated with CDK5RAP2 elisa kit
Pathways associated with CDK5RAP2 elisa kit
Organs/Tissues associated with CDK5RAP2 elisa kit
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