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| Product Name
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Cathepsin S (Cath-S), ELISA Kit
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| Also Known As
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Canine Cathepsin S ELISA Kit
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| Request for Current Manual Insert
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| OMIM
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116845
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| Species Reactivity
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Canine
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| Samples
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Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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| Assay Type
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Competitive
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| Detection Range
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100-2500pg/mL
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| Sensitivity
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1.0pg/mL
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| Preparation and Storage
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Store all reagents at 2-8 degree C.
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| Sample Preparation
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We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
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| Product Note
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Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
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| Other Notes
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Small volumes of Cath-S elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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| Searchable Terms for Cath-S purchase
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MBS741720 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cathepsin S (Cath-S) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 100-2500pg/mL in biological research samples containing Cath-S, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS741720 kit is based on Cath-S antibody-Cath-S antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Cath-S antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Cath-S. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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| Product Categories/Family for Cath-S elisa kit
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Immunology
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| NCBI/Uniprot data below describe general gene information for Cath-S. It may not necessarily be applicable to this product. |
| NCBI GI #
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179957
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| NCBI GeneID
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1520
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| NCBI Accession #
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AAC37592.1
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[Other Products]
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| UniProt Secondary Accession #
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Q5T5I0; Q6FHS5; Q9BUG3; B4DWC9; D3DV05
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[Other Products]
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| UniProt Related Accession #
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P25774
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[Other Products]
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| Molecular Weight
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31,626 Da
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| NCBI Official Full Name
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cathepsin S
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| NCBI Official Synonym Full Names
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cathepsin S
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| NCBI Official Symbol
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CTSS
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[Similar Products]
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| NCBI Protein Information
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cathepsin S
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| UniProt Protein Name
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Cathepsin S
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| Protein Family
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Cathepsin
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| UniProt Gene Name
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CTSS
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[Similar Products]
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| UniProt Entry Name
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CATS_HUMAN
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| NCBI Summary for Cath-S
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The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
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| UniProt Comments for Cath-S
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CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.22.27; Protease
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: extracellular space; lysosomal lumen; membrane; intracellular membrane-bound organelle; lysosome; extracellular region
Molecular Function: collagen binding; proteoglycan binding; cysteine-type endopeptidase activity; fibronectin binding; laminin binding
Biological Process: extracellular matrix organization and biogenesis; adaptive immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis; antigen processing and presentation; extracellular matrix disassembly; collagen catabolic process; antigen processing and presentation of peptide antigen via MHC class I; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; immune response; positive regulation of inflammatory response
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| Research Articles on Cath-S
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1. Cat S-mediated autophagic flux is an important mechanism for inducing M2-type polarization of tumor-associated macrophages, which leads to tumor development
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with Cath-S elisa kit | Pathways associated with Cath-S elisa kit |
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| Diseases associated with Cath-S elisa kit | Organs/Tissues associated with Cath-S elisa kit |
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ELISA Kit 
